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【文摘发布】糖尿病的长期影响及其认知功能的
AUTHORS:Alan M. Jacobson, M.D. et al
SOURCE: <＜新英格兰医学杂志>＞Volume 356:1842-1852 May 3, 2007 Number 18
ABSTRACT:
Background Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia.
Methods A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study were examined on entry to the DCCT (at mean age 27 years) and a mean of 18 years later with the same comprehensive battery of cognitive tests. Glycated hemoglobin levels were measured and the frequency of severe hypoglycemic events leading to coma or seizures was recorded during the follow-up period. We assessed the effects of original DCCT treatment-group assignment, mean glycated hemoglobin values, and frequency of hypoglycemic events on measures of cognitive ability, with adjustment for age at baseline, sex, years of education, length of follow-up, visual acuity, self-reported sensory loss due to peripheral neuropathy, and (to control for the effects of practice) the number of cognitive tests taken in the interval since the start of the DCCT.
Results Forty percent of the cohort reported having had at least one hypoglycemic coma or seizure. Neither frequency of severe hypoglycemia nor previous treatment-group assignment was associated with decline in any cognitive domain. Higher glycated hemoglobin values were associated with moderate declines in motor speed (P=0.001) and psychomotor efficiency (P<0.001), but no other cognitive domain was affected.
Conclusions No evidence of substantial long-term declines in cognitive function was found in a large group of patients with type 1 diabetes who were carefully followed for an average of 18 years, despite relatively high rates of recurrent severe hypoglycemia. (ClinicalTrials.gov number, NCT00360893 [ClinicalTrials.gov] .)
http://content.nejm.org/cgi/content/abstract/356/18/1842 本人认领此文。如在48小时内未能提交译文，其他战友可自由认领。 TITLE: Long-Term Effect of Diabetes and Its Treatment on Cognitive Function
标题：糖尿病的长期影响及其认知功能的治疗
AUTHORS: Alan M. Jacobson, M.D. et al
作者：Alan M. Jacobson医学博士等
SOURCE: <＜新英格兰医学杂志>＞Volume 356:1842-1852 May 3, 2007 Number 18
来源：<＜新英格兰医学杂志>＞18期，356卷1842-1852页，2007年5月3日
ABSTRACT:
Background Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia.
摘要：
背景：使用不同治疗方法将血糖降低到接近正常范围，随之增加了患严重低血糖的风险，长期关注的1型糖尿病对认知能力影响也随之增加。
Methods A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study were examined on entry to the DCCT (at mean age 27 years) and a mean of 18 years later with the same comprehensive battery of cognitive tests. Glycated hemoglobin levels were measured and the frequency of severe hypoglycemic events leading to coma or seizures was recorded during the follow-up period. We assessed the effects of original DCCT treatment-group assignment, mean glycated hemoglobin values, and frequency of hypoglycemic events on measures of cognitive ability, with adjustment for age at baseline, sex, years of education, length of follow-up, visual acuity, self-reported sensory loss due to peripheral neuropathy, and (to control for the effects of practice) the number of cognitive tests taken in the interval since the start of the DCCT.
方法：共1144名1型糖尿病患者报名参加糖尿病控制和并发症试验(DCCT)及其后续的糖尿病干预和并发症的流行病防治计划(EDIC)的相关研究进入了DCCT（平均年龄27），并且平均18年后对该群体进行相同的认知测试。在这期间，糖化血红蛋白的含量被测量以及频繁的严重低血糖导致的昏厥或癫痫事件被记录。我们评估了原有的DCCT治疗组工作的效果，是指血红蛋白值，以及在测试认知能力时频繁的低血糖事件，以调整年龄基线，性别，受教育的年数以及随访时间，视力，由于神经末梢病变引起的知觉丧失的自我报告，并且（来控制练习的效果）自从开始DCCT后，在间隔的时候参与认知测试的次数。
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作者:admin@医学,生命科学 2011-03-10 17:12
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