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【medical-news】HPV负荷可有助于确定宫颈癌的危险
纽约（路透社健康新闻）－宫颈涂片中HPV16和18型的测定可有助于确定部分病人宫颈癌的危险性。这是《医学病毒学杂志》2006年第八期上一项法国研究者的报道。
该项研究的主要研究者Xavier Carcopino博士告诉路透社健康新闻版：“我们认为高HPV病毒负荷能够作为感染持续存在的预测因子，而HPV在宫颈癌的发展中起着重要作用。”
马赛的De la Timone医院的Carcopino博士及其合作者分别检查了97例具有异常的宫颈阴道涂片病人和54例因宫颈恶性肿瘤治疗后随访的病人，她们均在阴道镜检查前获得了宫颈刮片。
在两组30到40岁女性人中，高级别鳞状上皮内病变中HPV16病毒量显著高于低级别者。同样在初次筛查的人群中处于同一年龄的女性HPV18病毒负荷量也是如此。
然而，对于初次筛查的人群中年轻女性（20－30岁）者，高HPV病毒量与高或低级别鳞状上皮内病变中的关系不大。另外，高HPV量可见于部分正常宫颈组织的病人。
Carcopino博士继续谈到：“HPV16和18的检测不能够取代阴道镜检查，也不足以提示宫颈治疗。”
然而，他补充到，这个方法对年龄超过30岁者的病人可提供补充信息。“在异常的宫颈涂片病人，高HPV含量必须使临床医生在进行阴道镜检查时要特别注意。”
HPV Load May Help Determine Cervical Cancer Risk
NEW YORK (Reuters Health) Jul 26 - Quantification of human papillomavirus (HPV) type 16 and 18 viremia in cervical smears may help determine cervical cancer risk in certain patients, French researchers report in the August issue of the Journal of Medical Virology.
"We think that high HPV viral load can be used as predictive factor for infection persistence, which is critical in cancer development," lead investigator Dr. Xavier Carcopino told Reuters Health.
Dr. Carcopino of Hopital de la Timone, Marseille and co-investigators examined cervical scrapes obtained before colposcopy from 97 women with an abnormal cervico-vaginal smear and 54 who were undergoing follow-up after treatment for a cervical malignancy.
In women between 30 and 40 years old in both groups, HPV 16 viral loads were significantly higher in high-grade than low-grade squamous intraepithelial lesions. This was also true of HPV 18 loads in women of the same age in the initial screening group.
However, for younger women (20 to 30 years old) in the initial screening group, high HPV load was rarely associated with either high-grade or low-grade squamous intraepithelial lesions. In addition, high loads were seen in some of these patients with normal cervical tissue.
"HPV 16 and 18 quantification tests do not replace colposcopy and are not sufficient to indicate a cervical treatment," continued Dr. Carcopino.
However, he added, the approach brings complementary information in patients over the age of 30 years. "Used in a case of abnormal Pap smear, a high viral load must lead the physician to pay particular attention when performing the colposcopy." [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-09-01 05:12
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