马赛的De la Timone医院的Carcopino博士及其合作者分别检查了97例具有异常的宫颈阴道涂片病人和54例因宫颈恶性肿瘤治疗后随访的病人，她们均在阴道镜检查前获得了宫颈刮片。
HPV Load May Help Determine Cervical Cancer Risk
NEW YORK (Reuters Health) Jul 26 - Quantification of human papillomavirus (HPV) type 16 and 18 viremia in cervical smears may help determine cervical cancer risk in certain patients, French researchers report in the August issue of the Journal of Medical Virology.
"We think that high HPV viral load can be used as predictive factor for infection persistence, which is critical in cancer development," lead investigator Dr. Xavier Carcopino told Reuters Health.
Dr. Carcopino of Hopital de la Timone, Marseille and co-investigators examined cervical scrapes obtained before colposcopy from 97 women with an abnormal cervico-vaginal smear and 54 who were undergoing follow-up after treatment for a cervical malignancy.
In women between 30 and 40 years old in both groups, HPV 16 viral loads were significantly higher in high-grade than low-grade squamous intraepithelial lesions. This was also true of HPV 18 loads in women of the same age in the initial screening group.
However, for younger women (20 to 30 years old) in the initial screening group, high HPV load was rarely associated with either high-grade or low-grade squamous intraepithelial lesions. In addition, high loads were seen in some of these patients with normal cervical tissue.
"HPV 16 and 18 quantification tests do not replace colposcopy and are not sufficient to indicate a cervical treatment," continued Dr. Carcopino.
However, he added, the approach brings complementary information in patients over the age of 30 years. "Used in a case of abnormal Pap smear, a high viral load must lead the physician to pay particular attention when performing the colposcopy." [标签:content1][标签:content2]
作者:admin@医学,生命科学 2011-09-01 05:12