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【medical-news】类固醇激素可能消除COPD患者肺癌风
http://www.webmd.com/news/20070404/steroids-may-cut-copd-lung-cancer-risk
Steroids May Cut COPD Lung Cancer Risk
April 4, 2007 -- Taking inhaled corticosteroids may lower the risk of lung cancer among people with COPD (chronic obstructive pulmonary disease).
Lung cancer is a common cause of death among people with COPD.
A new study suggests people who took at least 1,200 micrograms per day of inhaled corticosteroids had a 61% lower risk of developing lung cancer than nonusers.
Researchers say inflammation in the lungs is thought to play an important role in both COPD and lung cancer, and the results suggest that daily use of inhaled corticosteroids may help fight inflammation and prevent the progression from COPD to lung cancer.
“Tobacco smoke is a well-recognized stimulant of systemic and local inflammation, and the role of inflammation in the causal pathway for both lung cancer and COPD has been suggested,” says researcher David H. Au, MD, of the University of Washington, Seattle, in a news release.
Smoking is a primary cause of COPD, which includes two inflammatory lung diseases that interfere with breathing: chronic bronchitis and emphysema. An estimated 11 million adults suffer from COPD.
Corticosteroids are powerful drugs used to treat inflammation and other conditions.
Preventing Lung Cancer?
Researchers followed a group of more than 10,000 mostly older male U.S. veterans with COPD who were treated in Veterans Affairs primary care clinics from 1996 to 2001. Of these, 517 were regular users of inhaled corticosteroids as determined by records of pharmacy refills and were included in the study's analysis.
The results, published in the American Journal of Respiratory and Critical Medicine, suggested that compared with nonusers of corticosteroids, those who took 1,200 micrograms or more per day of inhaled corticosteroids were 61% less likely to develop lung cancer during the course of the study.
The researchers note that this is an observational study that “cannot conclude that [inhaled corticosteroids] reduce lung cancer" and that the results need confirmation.
Researchers say no drugs have been clinically proven to prevent lung cancer among those at risk, but several are under investigation.
If further larger studies confirm these results, they say high doses of inhaled corticosteroids may play a potential role in reducing the risk of lung cancer among people with COPD. Previous studies have shown inhaled corticosteroids reduce markers of inflammation such as C-reactive protein and reduce airway inflammation. http://www.webmd.com/news/20070404/steroids-may-cut-copd-lung-cancer-risk
Steroids May Cut COPD Lung Cancer Risk
标题：类固醇激素可能消除COPD患者肺癌风险
April 4, 2007 -- Taking inhaled corticosteroids may lower the risk of lung cancer among people with COPD (chronic obstructive pulmonary disease).
2007年4月4日------吸入糖皮质激素可能降低慢性阻塞性肺病（COPD）患者的肺癌发病风险。
Lung cancer is a common cause of death among people with COPD.
肺癌是导致COPD患者死亡的常见原因。
A new study suggests people who took at least 1,200 micrograms per day of inhaled corticosteroids had a 61% lower risk of developing lung cancer than nonusers.
一项新研究表明每日至少吸入1200mg糖皮质激素比未吸入者发生肺癌的风险降低61%。
Researchers say inflammation in the lungs is thought to play an important role in both COPD and lung cancer, and the results suggest that daily use of inhaled corticosteroids may help fight inflammation and prevent the progression from COPD to lung cancer.
研究人员说，肺内炎症被认为在COPD和肺癌中具有重要角色，结果表明每日使用糖皮质激素吸入剂可能帮助抗炎、预防COPD进展至肺癌。
“Tobacco smoke is a well-recognized stimulant of systemic and local inflammation, and the role of inflammation in the causal pathway for both lung cancer and COPD has been suggested,” says researcher David H. Au, MD, of the University of Washington, Seattle, in a news release.
西雅图华盛顿大学 David H. Au博士在新闻中说：“香烟烟雾被一致认同为全身和局部炎症的刺激物，已表明炎症在肺癌和COPD发生的偶然路径的地位”。
Smoking is a primary cause of COPD, which includes two inflammatory lung diseases that interfere with breathing: chronic bronchitis and emphysema. An estimated 11 million adults suffer from COPD.
吸烟是导致COPD的主要原因，COPD包括2个影响呼吸的炎症性肺病：慢性支气管炎和肺气肿。估计11,000,000成人患者COPD.
Corticosteroids are powerful drugs used to treat inflammation and other conditions.
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作者:admin@医学,生命科学 2011-08-13 17:12
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