主页 > 医学文档 >
【medical-news】立普妥增加颅内出血风险
NEW YORK (Reuters Health) - The use of cholesterol-lowering "statin" drugs, such as Lipitor (atorvastatin) and Zocor (simvastatin), may raise the risk of brain hemorrhage in patients who have experienced a recent stroke or a transient ischemic attack (TIA), new research suggests. Still, this risk may be outweighed by the ability of these agents to lower the overall risk of a second stroke and other serious events, such as heart attack.
"This is a secondary analysis of data collected as part of the Stroke Prevention with Aggressive Reductions in Cholesterol Levels (SPARCL) study," lead author Dr. Larry B. Goldstein told Reuters Health.
The main finding of SPARCL, he said, was that atorvastatin reduced the risk of stroke by 16 percent in patients who recently had a stroke or TIA, a condition in which blood flow to a portion of the brain is temporarily reduced. However, in an unplanned analysis, atorvastatin seemed to slightly increase the risk of brain hemorrhage.
In the present study, reported in the journal Neurology, Goldstein, from Duke University Medical Center in Durham, North Carolina, and colleagues explored this association further by analyzing data from 4,731 SPARCL participants. Sixty-seven percent of subjects had a prior low-blood-flow or "ischemic" stroke, 31 percent had a TIA, and 2 percent had a stroke caused by a brain hemorrhage.
Treatment with atorvastatin increased the risk of brain hemorrhage by 68 percent, the report indicates.
A prior hemorrhagic stroke raised the risk of brain hemorrhage by more than fivefold. Other factors that increased the risk included male gender, which raised the risk by 79 percent, and age, which elevated the risk by 42 percent for every 10 years of age. Further analysis showed that having high blood pressure -- 160/100 mm Hg or higher -- at the last study visit increased the odds of brain hemorrhage by more than sixfold.
Goldstein noted that data from observational studies have suggested that low cholesterol levels raise the risk of brain hemorrhage. "Since statins lower cholesterol, it was reasonable to think that the risk of brain hemorrhage was due to cholesterol lowering. However, we found no relationship between the level of cholesterol lowering and this risk."
According to Goldstein, the main message from SPARCL is that treatment with atorvastatin can reduce the risk of stroke in patients with a recent ischemic stroke or TIA, and the risk of brain hemorrhage is small.
However, for patients who have already had a hemorrhagic stroke, which constituted 2 percent of the study group, atorvastatin therapy did not seem to be beneficial.
http://www.reuters.com/article/healthNews/idUSFLE27759720071212 Cholesterol drugs may raise brain hemorrhage risk
降胆固醇的药物可能会增加脑出血风险
NEW YORK (Reuters Health) - The use of cholesterol-lowering "statin" drugs, such as Lipitor (atorvastatin) and Zocor (simvastatin), may raise the risk of brain hemorrhage in patients who have experienced a recent stroke or a transient ischemic attack (TIA), new research suggests. Still, this risk may be outweighed by the ability of these agents to lower the overall risk of a second stroke and other serious events, such as heart attack.
纽约（路透社 健康部）－一项新的研究显示，在那些最近有中风和短暂性缺血发作经历的患者中使用降胆固醇的“他汀”类药物，如立普妥（阿托伐他汀）和舒降之（辛戈他丁），可能增加脑出血的危险性。
"This is a secondary analysis of data collected as part of the Stroke Prevention with Aggressive Reductions in Cholesterol Levels (SPARCL) study," lead author Dr. Larry B. Goldstein told Reuters Health.
“这是对强化降胆固醇治疗对卒中预防(SPARCL)研究所收集的数据的再次统计分析，也是SPARCL研究的一部分。”本文的第一作者，Larry B. Goldstein医生对路透社这样说。
The main finding of SPARCL, he said, was that atorvastatin reduced the risk of stroke by 16 percent in patients who recently had a stroke or TIA, a condition in which blood flow to a portion of the brain is temporarily reduced. However, in an unplanned analysis, atorvastatin seemed to slightly increase the risk of brain hemorrhage.
他说，SPARCL研究最大的发现是：阿托伐他汀能降低16％在最近有卒中和短暂性缺血（就是一部分的脑血流暂时性的减少的情况）发作经历的患者的再次卒中的危险。尽管如此，在一个不是计划中的分析中却发现，阿托伐他汀似乎可以轻微的增加脑出血的危险性。
In the present study, reported in the journal Neurology, Goldstein, from Duke University Medical Center in Durham, North Carolina, and colleagues explored this association further by analyzing data from 4,731 SPARCL participants. Sixty-seven percent of subjects had a prior low-blood-flow or "ischemic" stroke, 31 percent had a TIA, and 2 percent had a stroke caused by a brain hemorrhage.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-08-05 06:26
医学,生命科学网