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【medical-news】微小RNA在神经发生中的功能
Main Category: Neurology / Neuroscience News
Article Date: 09 Oct 2006 - 8:00am (PDT)
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In the October15th issue of G&D, Dr. Fen-Biao Gao and colleagues at UCSF report that microRNA-9a (mir-9a) regulates neural development in the fruit fly, Drosophila. Using loss-of-function analysis, Dr. Gao and colleagues demonstrate that mir-9a is required for the precise production of sensory organ precursor cells in the Drosophila peripheral nervous system (PNS). mir-9a-mutant embryos form additional PNS neurons, and mutant adults wings display extra sensory bristles. The researchers show that mir-9a post-transcriptionally represses the transcription factor, Senseless, to regulate the precise number of neuronal precursor cells in Drosophila embryos and adults. "miR-9a is 100% conserved from flies to humans at the nucleotide sequence level and is highly expressed in fetal brains, suggesting that a similar mechanism may operate in mammalian neurogenesis as well," explains Dr. Gao.
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Contact: Heather Cosel
Cold Spring Harbor Laboratory 微小RNA在神经发生中的功能
主要类别：神经学/神经科学消息
报道日期：2006年10月9日，上午8：00（太平洋标准时间）
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在UCSF工作的Fen-Biao Gao博士和其合作者在10月份G&D杂志第十五版上报道：微小RNA-9a（mir-9a）调节果蝇的神经发育。Gao博士和其合作者采用功能缺失分析证明果蝇外周神经系统（PNS）感觉器官前体细胞的精确产生需要mir-9a的参与。mir-9a突变体胚胎可形成额外的PNS神经元，突变体成体则表现为额外的感觉鬃。研究者表明mir-9a转录后抑制转录因子，以便调控果蝇在胚胎的神经前体细胞的精确数量，这似乎是毫无意义的。Gao博士解释说：“在核甘酸序列水平，从果蝇到人类，mir-9a是100%的保守，并且mir-9a在胎儿脑组织中高度表达，这表明一种相似的机制可能控制着哺乳动物的神经发生。”
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联系: Heather Cosel
Cold Spring Harbor Laboratory [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-07 05:12
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