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【medical-news】变更婴幼儿营养能阻止1型糖尿病发
Can We Prevent Type 1 Diabetes By Modifying Infant Nutrition? (Brussels, 28 Nov 2006, 2pm-4pm)
Type 1 diabetes is a growing health problem among European children. European data indicate that the disease incidence has increased five- to six-fold among children under the age of 15 years after World War II, and there are no signs that the increase in incidence is levelling off. The most conspicuous increase has been seen among children under the age of 5 years. The EU-funded Diabetes Prevention study is generating a wealth of information on breast-feeding practices, infant nutrition and growth in young children in various countries. Newborn infants observed in Northern Europe (NE) had a higher birth weight but a shorter birth length than infants in Central and Southern Europe (CSE). The NE children remained heavier than those from CSE at least up to the age of 18 months. The NE children were also taller than the CSE children starting already from the age of 3 months up to the age of 18 months. Accelerated growth in infancy has been identified as a risk factor for type 1 diabetes later in childhood. Accordingly the observed growth pattern may contribute to the higher incidence of type 1 diabetes in NE compared to CSE.
Within the next 10 years the Diabetes Prevention study will generate a definite answer to the question whether early nutritional modification may prevent type 1 diabetes later in childhood. A reduction of 50% in the incidence of type 1 diabetes would have a substantial impact on the quality of life of many European families and would reduce future health care costs considerably in every European country.
The Diabetes Prevention study is the first study ever aimed at primary prevention of type 1 diabetes. The study is designed to provide an answer to the question whether weaning to a highly hydrolysed formula in infancy decreases the risk of future diabetes. All subjects are observed for 10 years to gain information on whether the dietary recommendations for infants at increased genetic risk of type 1 diabetes should be revised.
Starting in May 2002, 76 study centres from 15 countries (Australia, Canada, the Czech Republic, Estonia, Finland, Germany, Hungary, Italy, Luxembourg, the Netherlands, Poland, Spain, Sweden, Switzerland and USA) have been recruiting families for the Diabetes Prevention study. To be eligible the newborn infant has to have at least one family member (mother, father and/or sib) affected by type 1 diabetes and carry a HLA genotype conferring increased risk for type 1 diabetes. The initial recruitment target of 2032 eligible infants was reached at the beginning of September 2006, but the Study Group has decided to continue recruitment till the end of December 2006 (when the EU contribution will finish) to make the study even more powerful statistically. A majority of the study participants (52%) have been recruited in Europe. The International Coordinating Centre (ICC) is located at the University of Helsinki, Helsinki, Finland and the Data Management Unit (DMU) at the University of South Florida, Tampa, Florida, USA. The trial has logistically been a true challenge for both the ICC and DMU. DMU has been successful in establishing a secure, real-time, web-based, interactive data management system that works extremely well. This system can be directly applied to future international multicentre studies. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Can We Prevent Type 1 Diabetes By Modifying Infant Nutrition? (Brussels, 28 Nov 2006, 2pm-4pm)通过改变婴儿的营养方式，可以防止一型糖尿病的发生。
Type 1 diabetes is a growing health problem among European children. 在欧洲，儿童患一型糖尿病越来越受到人们的关注。European data indicate that the disease incidence has increased five- to six-fold among children under the age of 15 years after World War II, and there are no signs that the increase in incidence is levelling off. 欧洲的数据显示，在第二次世界大战之后，15岁以下罹患一型糖尿病的儿童人数增加了5 ~ 6倍。The most conspicuous increase has been seen among children under the age of 5 years. 其中增长最显著的是5岁以下的儿童。The EU-funded Diabetes Prevention study is generating a wealth of information on breast-feeding practices, infant nutrition and growth in young children in various countries. 欧洲糖尿病预防基金通过研究不同国家母乳喂养方式、婴儿营养、幼儿的生长，获得了宝贵的资料。Newborn infants observed in Northern Europe (NE) had a higher birth weight but a shorter birth length than infants in Central and Southern Europe (CSE). 北欧出生的婴儿比中欧或南欧的重而且身长短。The NE children remained heavier than those from CSE at least up to the age of 18 months. 北欧幼儿甚至在18个月内都比中欧或南欧的重。 The NE children were also taller than the CSE children starting already from the age of 3 months up to the age of 18 months. 北欧的孩子从3个月起到18个月大时比中欧或南欧的高。Accelerated growth in infancy has been identified as a risk factor for type 1 diabetes later in childhood. Accordingly the observed growth pattern may contribute to the higher incidence of type 1 diabetes in NE compared to CSE.我们可观察的生长方式，可能会使患1型糖尿病的风险增加，比较其在北欧和中南欧的不同，据此，目前认为婴儿期的加速生长是儿童期罹患1型糖尿病的危险因素之一。
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作者:admin@医学,生命科学 2011-06-11 05:14
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