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【drug-news】AACE系列报道：维生素D有助于血糖控制
SEATTLE, WA -- April 16, 2007 -- Vitamin D does not seem to be associated with glycaemic control in subjects with diabetes mellitus, according to findings presented here at the American Association of Clinical Endocrinologists 16th Annual Meeting and Clinical Congress (AACE).
In a poster session on April 12th Jayalakshmi Udayasankar, MBBS, endocrine fellow, division of medicine, University of Washington, Seattle, Washington, United States and colleagues noted that there are conflicting results among the few studies that have looked into the effect of vitamin D replacement on glycaemic control in type 2 diabetes.
The researchers examined serum 25-(OH)D and plasma haemoglobin A1c (HbA1c) levels in 24 patients with type 1 diabetes and 29 with type 2 diabetes between May and October of 2006. Those whose 25-(OH)D were lower than 30 ng/mL were given 1200 IU of vitamin D each day.
Eighty-six percent (46/53) had insufficient levels of 25-(OH)D during the initial visit. The researchers found a negative correlation between age and 25-(OH)D levels (P = .04). No correlation was observed between 25-(OH)D and HbA1c (P = .55), and a subanalysis separating the type 1 and type 2 subjects also did not show correlation (P = .83 and P = .28, respectively).
There were no correlations between 25-(OH)D and HbA1c levels in the low, middle or high tertiles of the initial 25-(OH)D level (P = .46, P = .06 and P = .22 respectively).
Nineteen percent (9/46) of participants who received vitamin D replacement therapy had follow-up measures of both 25-(OH)D and HbA1c during the study. All of these patients had 25-(OH)D levels greater than 30 ng/mL.
No significant correlation was found between the change in 25-(OH)D and HbA1c after vitamin D replacement.
A key finding is that the team did not see any significant correlation between vitamin D status and glycaemic control even after separating the data for type 1 diabetes and type 2 diabetes. Notably, increasing vitamin D levels did not show a trend toward improved glycaemic control.
The researchers noted that their findings may be limited by the small number of participants with follow up data, as do not account for the influence of subject characteristics known to impact glycaemic control.
Though vitamin D did not seem to be associated with glycaemic control in subjects in this study, Udayasankar noted there is room for more research. "Ours was a small study. What's needed are more prospective controlled trials on vitamin D in diabetes," she said. "Vitamin D is a public health measure that could have a lot of impact." Does Vitamin D Play a Role in Glycaemic Status? Presented at AACE
AACE系列报道：维生素D有助于血糖控制吗？
SEATTLE, WA -- April 16, 2007 -- Vitamin D does not seem to be associated with glycaemic control in subjects with diabetes mellitus, according to findings presented here at the American Association of Clinical Endocrinologists 16th Annual Meeting and Clinical Congress (AACE).
西雅图，华盛顿州——2007年4月16日——按照在美国内分泌学家协会第十六届年会和临床会议中提出的发现，维生素D看起来与糖尿病受试者的血糖控制无关。
In a poster session on April 12th Jayalakshmi Udayasankar, MBBS, endocrine fellow, division of medicine, University of Washington, Seattle, Washington, United States and colleagues noted that there are conflicting results among the few studies that have looked into the effect of vitamin D replacement on glycaemic control in type 2 diabetes.
在四月十二号的会议张贴中，Jayalakshmi Udayasankar（医学学士，美国华盛顿州西雅图市华盛顿大学医学院内分泌研究员）和同事发现少数关于维生素D置换在2型糖尿病血糖控制效果的研究结果互相矛盾。
The researchers examined serum 25-(OH)D and plasma haemoglobin A1c (HbA1c) levels in 24 patients with type 1 diabetes and 29 with type 2 diabetes between May and October of 2006. Those whose 25-(OH)D were lower than 30 ng/mL were given 1200 IU of vitamin D each day.
研究者在2006年5月~10月间检测24名1型糖尿病患者和29名2型糖尿病患者血清25-羟维生素D和血浆血红蛋白A1c (HbA1c)浓度。25-羟维生素D浓度低于30ng/mL的患者每天给予1200 IU维生素D。
Eighty-six percent (46/53) had insufficient levels of 25-(OH)D during the initial visit. The researchers found a negative correlation between age and 25-(OH)D levels (P = .04). No correlation was observed between 25-(OH)D and HbA1c (P = .55), and a subanalysis separating the type 1 and type 2 subjects also did not show correlation (P = .83 and P = .28, respectively).
86%的患者（46/53）在开始就诊时存在25-羟维生素D缺乏。研究者发现年龄和25-羟维生素D之间存在负相关(P = 0.04)。在25-羟维生素D和血红蛋白A1c之间无相关性(P = 0.55)，当分为1型糖尿病和2型糖尿病患者后，其间也没有相关性(P值分别为0.83和0.28)。
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作者:admin@医学,生命科学 2011-06-07 05:11
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