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【medical-news】Ecstasy neurotoxic even after first-time us
11/29/2006
By: Reuters Health
NEW YORK (Reuters Health), Nov 29 - Taking the drug ecstasy (also known by its chemical name MDMA), even just a few times, can harm the brain, according to the results of first study to look at the neurotoxic effects of low doses of the illegal "club drug" in first-time ecstasy users.
Brain imaging studies performed in 56 nonusers and 59 first-time ecstasy users, who had taken an average of just six tablets, revealed subtle changes in cell architecture and decreased blood flow in some areas of the brain in the young adults.
A decrease in verbal memory was also seen in new ecstasy users compared with nonusers, Dr. Maartje de Win of Academic Medical Center at the University of Amsterdam reported Monday at the annual meeting of the Radiological Society of North America (RSNA) in Chicago.
"These memory changes were quite subtle but they were measurable," she noted in an interview with Reuters Health.
It's not known where these harmful effects on the brain are fleeting or permanent. "There is some evidence, in heavy ecstasy users, that part of the brain recovers," de Win said, "although we don't know if brain cells recover, whether their function is the same."
Studies have shown that long-term or heavy ecstasy use can damage neurons in the brain and cause depression, anxiety, confusion, difficulty sleeping, and memory impairment. De Win's study, however, is the first to look at the neurotoxic effects of low doses of ecstasy on first-time users.
Ecstasy, which is highly addictive, stimulates the release of the brain chemical serotonin, producing a high that lasts from several minutes to an hour. The drug's "feel-good" effects vary by the individual, the dose and purity, and the environment in which it is taken. The drug can also produce hallucinogenic effects.
Ecstasy burst onto the club scene in the 1980s and its use escalated in the 1990s, particularly among adolescents and young adults. In 2005, the National Institute on Drug Abuse estimated that 5.4% of all graduating seniors in the U.S. had tried the drug at least once.
"Our study shows that, even in small doses, ecstasy may harm the brain and people should be informed of this risk," de Win warned.
Last Updated: 2006-11-28 16:39:31 -0400 (Reuters Health) 本人已经认领此文. 如在48小时内未能提交译文, 其他战友可自由认领. Ecstasy neurotoxic even after first-time use
11/29/2006
By: Reuters Health
第一次使用摇头丸就有神经毒性
NEW YORK (Reuters Health), Nov 29 - Taking the drug ecstasy (also known by its chemical name MDMA), even just a few times, can harm the brain, according to the results of first study to look at the neurotoxic effects of low doses of the illegal "club drug" in first-time ecstasy users.
纽约（路透社 健康），
一项研究初次使用低剂量的非法“俱乐部毒品”——“摇头丸”（化学名MDMA）的使用者的神经毒性作用的结果显示：服用摇头丸，甚至只有几次，也能损伤大脑。
Brain imaging studies performed in 56 nonusers and 59 first-time ecstasy users, who had taken an average of just six tablets, revealed subtle changes in cell architecture and decreased blood flow in some areas of the brain in the young adults.
对56个非使用者和59个初次摇头丸使用者进行了脑成像研究，其中初次摇头丸使用者平均使用6片。结果显示在年轻人中某些脑区的细胞结构发生微细改变和血流降低。
A decrease in verbal memory was also seen in new ecstasy users compared with nonusers, Dr. Maartje de Win of Academic Medical Center at the University of Amsterdam reported Monday at the annual meeting of the Radiological Society of North America (RSNA) in Chicago.
阿姆斯特丹大学军事医学中心的Maartje de Win医生星期一在芝加哥召开的北美放射协会年会上报道说：还观察到初次使用摇头丸的使用者的语言记忆能力与非使用者相比有下降。
"These memory changes were quite subtle but they were measurable," she noted in an interview with Reuters Health.
她在路透社健康频道的访谈中说，这些记忆改变十分微细，但是可以测量得到。
It's not known where these harmful effects on the brain are fleeting or permanent. "There is some evidence, in heavy ecstasy users, that part of the brain recovers," de Win said, "although we don't know if brain cells recover, whether their function is the same."
de Win医生说：现在还不知道这些对脑组织的损伤是暂时性的还是永久性的。有证据显示在严重的摇头丸使用这中部分可以恢复。“我们不知道脑细胞是否恢复，也不知道功能是否恢复。
Studies have shown that long-term or heavy ecstasy use can damage neurons in the brain and cause depression, anxiety, confusion, difficulty sleeping, and memory impairment. De Win's study, however, is the first to look at the neurotoxic effects of low doses of ecstasy on first-time users.
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作者:admin@医学,生命科学 2011-06-03 05:14
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