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【medical-news】无创输入胰岛素为糖尿病患者带来
论文作者：Mariko Mori***a 期刊：《先进药物输送评论》
现在还有很多糖尿病患者每天都要忍受皮肉之苦，一天数次地通过注射摄入足够分量的胰岛素以治疗病情，还有很多患者对注射怀有恐惧心理，以及对针管的担忧耽误了治疗。近年来药物学家正在探索无创或者微创的给药方式，包括口服、颊部给药、鼻腔给药、肺部给药、眼给药、直肠给药以及透皮给药等等，这将给人类攻克这种发病率日益上升的“杀手”提供新的“武器”。
目前，口服、颊面、肺部以及鼻腔给药都取得了重要的进展。口服给药对于患者最方便，Ⅱ型糖尿病患者正在进行临床二期的治疗，他们首次服用胶囊，使用的是没有酰化的氨基酸作为载体，使得多肽能够进入血液，载体在输送药物的时候不会改变药物的构造，但是可以改变物理性质，当然就不会影响药物的有效性，而且口服胰岛素可以提高血液中胰岛素的浓度；而有些药物通过鼻腔给药,其起效之快超过了口服,甚至超过肌肉注射及皮下注射。
尽管现在各种给药方法还需要很多临床实验，但是很多药物输送公司和科研机构都在积极研究和发展口服胰岛素的输送系统，糖尿病患者今后可望免除年复一年、日复一日或一日数次注射胰岛素的痛苦。
相关论文发表在2007年12月22日的爱思唯尔期刊《先进药物输送评论》（Advanced Drug Delivery Reviews）上。（科学新闻杂志 周媛媛/编译）
糖尿病患者注射胰岛素
screen.width-333)this.width=screen.width-333" width=300 height=202 title="Click to view full 1.jpg (300 X 202)" border=0 align=absmiddle> Current challenges in non-invasive insulin delivery systems: A comparative review
El-Sayed Khafagya, Mariko Mori***a, a, , Yoshinori Onukia and Kozo Takayamaa
aDepartment of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142-8501, Japan
Received 23 March 2007; accepted 16 August 2007. Available online 22 August 2007.
Abstract
The quest to eliminate the needle from insulin delivery and to replace it with non- or less-invasive alternative routes has driven rigorous pharmaceutical research to replace the injectable forms of insulin. Recently, various approaches have been studied involving many strategies using various technologies that have shown success in delivering insulin, which are designed to overcome the inherent barriers for insulin uptake across the gastrointestinal tract, mucosal membranes and skin. This review examines some of the many attempts made to develop alternative, more convenient routes for insulin delivery to avoid existing long-term dependence on multiple subcutaneous injections and to improve the pharmacodynamic properties of insulin. In addition, this article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modern insulin delivery for the effective treatment of diabetes.
Keywords: Non-invasive delivery system; Modern insulin delivery; Administration routes; Marketed products; Formulation technologies; Future patents
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T3R-4PGGNXP-5&_user=10&_coverDate=12%2F22%2F2007&_rdoc=5&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%234953%232007%23999409984%23674731%23FLA%23display%23Volume)&_cdi=4953&_sort=d&_docanchor=&_ct=7&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c9d5ce76285036e3aa77f5cec4e3a4b5 中文稿来自科学网吧
我认领英文翻译，48小时后若未提交译文，请其他战友自由认领。 Current challenges in non-invasive insulin delivery systems: A comparative review
无创性胰岛素输入系统的挑战：一项对比回顾研究
Abstract
摘要
The quest to eliminate the needle from insulin delivery and to replace it with non- or less-invasive alternative routes has driven rigorous pharmaceutical research to replace the injectable forms of insulin.
将胰岛素输入装置的针头去除、并以无创或是微创的方法来取而代之的需求，激发各个医药公司开展严酷的研发竞争将注射式的胰岛素输入方式更新换代。
Recently, various approaches have been studied involving many strategies using various technologies that have shown success in delivering insulin, which are designed to overcome the inherent barriers for insulin uptake across the gastrointestinal tract, mucosal membranes and skin.
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作者:admin@医学,生命科学 2011-05-28 05:14
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