主页 > 医学文档 >
【文摘发布】妊娠糖尿病期间出现GAD抗体预示1型
DOI: 10.2337/dc07-0157
TITLE: Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes
AUTHOR: Charlotta Nilsson, MD, Dag Ursing, MD.et al.
ABSTRACT
OBJECTIVE: To study the frequency of have beta-cell specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type 1 diabetes.
RESEARCH DESIGN AND METHODS: Out of 385 pregnant women with GDM during 1995 to 2005 in the district of Lund, 24 women (6%) were found positive for at least one of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase antibodies (IA-2A). These women were followed and autoantibodies were reanalyzed and those who had not developed diabetes did an oral glucose tolerance test (OGTT). Known risk factors for both GDM and type 1 diabetes were compared to women who had GDM but without pancreatic autoantibodies.
RESULTS: Among the autoantibody positive women 50% had developed type 1 diabetes compared to none among the GDM controls (p=0.001), 21% had impaired fasten glucose (IFG) or impaired glucose tolerance (IGT) compared to 12,5% (p=0.3) and none had developed type 2 diabetes compared to 12.5% among controls (p=0.1).
CONCLUSIONS: Autoantibody screening in pregnant women with GDM should be considered for early recognition of type 1 diabetes and subsequent follow up after delivery. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 版主对不起，宝马同志被通知明日上班24小时，无法高质完成翻译，请见谅。请其它战友认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 RESOURCE: Diabetes Care Publish Ahead of Print published online ahead of print May 22, 2007
来源：糖尿病护理 2007年5月22日
DOI: 10.2337/dc07-0157
TITLE: Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes
题目：妊娠糖尿病期间出现GAD抗体可预测继发1型糖尿病
AUTHOR: Charlotta Nilsson, MD, Dag Ursing, MD.et al.
ABSTRACT
摘要
OBJECTIVE: To study the frequency of have beta-cell specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type 1 diabetes.
目的：研究在妊娠糖尿病(GDM)妇女胰腺β-细胞特异性自身抗体标志物表达率并随访评估继后发生1型糖尿病风险。
RESEARCH DESIGN AND METHODS: Out of 385 pregnant women with GDM during 1995 to 2005 in the district of Lund, 24 women (6%) were found positive for at least one of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase antibodies (IA-2A). These women were followed and autoantibodies were reanalyzed and those who had not developed diabetes did an oral glucose tolerance test (OGTT). Known risk factors for both GDM and type 1 diabetes were compared to women who had GDM but without pancreatic autoantibodies.
研究设计和方法：1995-2005年，隆德地区385例妊娠糖尿病妇女纳入，24例患者(6%)至少一项β-细胞抗体(ICA)或谷氨酸脱羧酶抗体(GADA)或酪氨酸磷酸酶(IA-2A)阳性。这部分患者随访并再次检测自身抗体，后来未发展为糖尿病患者经口服葡萄糖耐量试验(OGTT)证实。在妊娠糖尿病继发1型糖尿病患者与不继发1型糖尿病患者两组中比较已知的胰腺自身抗体危险因子。
RESULTS: Among the autoantibody positive women 50% had developed type 1 diabetes compared to none among the GDM controls (p=0.001), 21% had impaired fasten glucose (IFG) or impaired glucose tolerance (IGT) compared to 12,5% (p=0.3) and none had developed type 2 diabetes compared to 12.5% among controls (p=0.1).
结果：在胰腺自身抗体阳性组中，50%患者继发1型糖尿病，与自身抗体阴性组比较，1型糖尿病发病率有统计学差异(p=0.001)；阳性组21%患者血糖调节能力降低(IFG)或葡萄糖耐量降低(IGT)，阴性组12.5%患者IFG或IGT，两者无差异(p=0.3)；阴性组与阳性组（12.5%）2型糖尿病发病率未见差异(p=0.1)。
CONCLUSIONS: Autoantibody screening in pregnant women with GDM should be considered for early recognition of type 1 diabetes and subsequent follow up after delivery.
在妇女妊娠糖尿病1型糖尿病早期诊断和分娩后随访中，可考虑采用自身抗体筛查方法。 编译：中文字数（376）
2007年5月22日瑞典隆德大学医院内分泌学糖尿病科Charlotta Nilsson博士和同事们在《糖尿病护理》杂志发表了一篇研究论文，该研究针对妇女妊娠糖尿病继发1型糖尿病，结果表明在妇女妊娠糖尿病继发1型糖尿病早期诊断和分娩后随访中，可考虑采用自身抗体筛查方法。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-29 17:11
医学,生命科学网