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【medical-news】肌肉成分补充无助COPD患者
Sarah Deacon (Glenfield Hospital, Leicester, UK) and colleagues explain in the American Journal of Respiratory and Critical Care Medicine that dietary creatine supplementation has been shown to increase muscle mass in athletes and healthy elderly people who undertake high-intensity exercise training.
Reduced skeletal muscle strength and bulk is a major feature of COPD and detracts from patients' ability to carry out everyday tasks, so the authors reasoned that if creatine had a similar muscle-building effect in COPD patients it could effectively augment pulmonary rehabilitation.
To examine the effect of creatine on functional exercise capacity and muscle performance in patients with COPD, Deacon and team randomly assigned 100 COPD patients to receive either creatine at a 22 g/day loading dose for 5 days followed by maintenance therapy at 3.7 6 g/day, or placebo during 7 weeks of pulmonary rehabilitation consisting of aerobic and resistance exercises.
Pulmonary rehabilitation increased the exercise capacity of both groups, but there was no significant difference in improvement between the two groups.
However, pre- and post-loading quadriceps muscle biopsies taken from 31 volunteers did show evidence of creatine uptake.
"Creatine supplementation does not augment the substantial training effect of multidisciplinary pulmonary rehabilitation for patients with COPD," the authors write.
"We have evidence to suggest creatine uptake into muscles but are unable to explain why an increase in muscle creatine did not enhance training."
The team concludes: "Future work could look more closely at the effects of creatine supplementation on muscle protein synthesis and oxidative stress."
Am J Repir Crit Care Med 2008; 178: 233?39
Muscle-building supplement has no benefit for COPD patients [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-24 05:14
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