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【社会人文】社会心理因素显著增加心脏病风险
30 January 2007
Research suggests that cynical and distrustful traits, along with stress and depression, significantly increase circulating inflammatory markers that are associated with cardiovascular disease (CVD) risk.
Stress and other psychosocial factors have previously been linked to an increased risk of CVD, but the reasons for this remain unclear, explain Nalini Ranjit, from the University of Michigan in Ann Arbor, USA, and colleagues.
To investigate further, the researchers used questionnaires to assess levels of cynical distrust, long-term stress, and depression in 6814 men and women aged between 45 and 84 years.
They also measured blood levels of the inflammatory markers interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen.
The results, published in the Archives of Internal Medicine, indicated that levels of cynical distrust, chronic stress and depression were all associated with increased levels of inflammation.
The greatest association was seen for cynical distrust, which was linked to all three of the inflammatory markers studied, followed by chronic stress, which was associated with IL-6 and, to a lesser extent, CRP, and depression, which was associated only with IL-6.
Associations between these factors and inflammatory markers weakened after taking into account body mass index (BMI), and behaviors such as smoking, although they remained significant.
However, no associations remained after additionally controlling for socioeconomic position and diabetes.
The findings suggest that part of the link between these factors and CVD risk may be mediated by behaviors (for example, stress causing smoking which in turn elevates inflammation), and obesity and related metabolic problems.
In addition, the authors write, "socioeconomic position is likely to be an antecedent to psychosocial characteristics, as well as to other factors… associated with inflammation."
The team thus concludes that these cross-sectional results are compatible with a mediating role of behaviors, BMI, and diabetes, "although definite conclusions regarding mediation can only be drawn from longitudinal designs."
Arch Intern Med 2007; 167: 174–181
http://www.incirculation.net/NewsItem/Psychosocial-factors-linked-to-heart-disease-risk.aspx 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Psychosocial factors linked to heart disease risk
心理社会因素与心脏病发病风险有关
30 January 2007
Research suggests that cynical and distrustful traits, along with stress and depression, significantly increase circulating inflammatory markers that are associated with cardiovascular disease (CVD) risk.
2007年1月30日
研究显示，愤世嫉俗和怀疑的态度同时具有压抑和抑郁，显著增加了与心血管疾病(CVD)风险有关的循环系统炎症标记物的水平。
Stress and other psychosocial factors have previously been linked to an increased risk of CVD, but the reasons for this remain unclear, explain Nalini Ranjit, from the University of Michigan in Ann Arbor, USA, and colleagues.
来自美国Ann Arbor的密西根州立大学的Nalini Ranjit和他的同事解释说：以前就曾发现压抑和其他社会心理因素和CVD风险增加有关，但是其原因一直没有搞清。
To investigate further, the researchers used questionnaires to assess levels of cynical distrust, long-term stress, and depression in 6814 men and women aged between 45 and 84 years.
为了进一步的研究，研究人员对年龄在45到84岁之间的6814个男性和女性进行了问卷调查，对其不信任感、长期压抑和抑郁的程度进行评估。
They also measured blood levels of the inflammatory markers interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen.
他们也检测了炎症标记物白介素-6、C-反应蛋白和纤维蛋白原的血浆水平。
The results, published in the Archives of Internal Medicine, indicated that levels of cynical distrust, chronic stress and depression were all associated with increased levels of inflammation.
其结果发表在内科学杂志上，表明不信任感、长期压抑和抑郁的程度都与炎症标记物水平增高有关。
The greatest association was seen for cynical distrust, which was linked to all three of the inflammatory markers studied, followed by chronic stress, which was associated with IL-6 and, to a lesser extent, CRP, and depression, which was associated only with IL-6.
不信任感与其关联最大，其与研究的三种炎症标记物都有关系，其次是长期的压抑，其与IL-6有关，与CRP轻微相关，而抑郁只与IL-6相关。
Associations between these factors and inflammatory markers weakened after taking into account body mass index (BMI), and behaviors such as smoking, although they remained significant.
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作者:admin@医学,生命科学 2011-02-25 05:11
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