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【Nature】推介论文：点亮抑郁
A reduction in the activity of neurons in the brain's prefrontal cortex is probably a cause, rather than a consequence, of depressive behaviours.
Eric Nestler at Mount Sinai School of Medicine in New York and his colleagues found, at post-mortem, unusually low expression of key genes in parts of the prefrontal cortex of people with depression. Mice displaying depressive behaviours after being repeatedly defeated by aggressive mice showed similar gene-expression changes in the same brain region. However, some resilient animals showed neither these behaviours nor reduced gene activity.
The researchers then used light to directly activate cortical neurons in the mice, which had been engineered to overexpress a light-sensitive protein in these cells. The depressive behaviour of susceptible mice was reversed — without affecting other behaviours such as movement or social memory.
原文连接
Covington HE 3rd, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, LaPlant Q, Mouzon E, Ghose S, Tamminga CA, Neve RL, Deisseroth K, Nestler EJ. 2010. Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci. 2010 Dec 1;30(48):16082-90.http://www.ncbi.nlm.nih.gov/pubmed/21123555 鼻腔内低强度激光照射（附录一）也可以治疗抑郁，详细讨论参见如下专著
刘承宜 朱平 主编. 2009. 低强度激光鼻腔内照射疗法. 北京：人民军医出版社。
刘承宜, 朱平 主编. 2011. 激光功能医学及其应用. 香港：精英出版社.
附录一 【讨论】鼻腔内低强度激光治疗
http://www.dxy.cn/bbs/post/view?bid=148&id=11031966&tpg=1&ppg=1&sty=1#11032115
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作者:admin@医学,生命科学 2011-02-17 11:03
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