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【drug-news】抗抑郁药促进中风后脑功能的 恢复
Antidepressant may boost brain function after stroke
Fri Mar 16, 2007 5:55PM EDT
NEW YORK (Reuters Health) - Impaired cognitive function is common and often permanent following stroke. However, new study findings suggest that treatment with antidepressants may help stroke sufferers recover brain function and improve psychological and social capacities.
Dr. Sergio Paradiso and associates at the University of Iowa Carver College of Medicine in Iowa City studied 47 stroke patients being admitted to a rehabilitation center. They were randomly assigned to an older antidepressant called nortriptyline, the newer antidepressant Prozac, or inactive placebo.
The patients were evaluated after 12 weeks of treatment and again 21 months later.
The investigators observed no differences among the treatment groups in executive function (overall reasoning and functioning) at the first evaluation or in overall cognitive functioning at the 12- and 21-month evaluations.
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However, at the final assessment, those given an antidepressant demonstrated marked improvement in executive function, independent of whether they were depressed.
In contrast, all but one of the placebo-treated patients had deteriorated significantly.
In the final analysis taking into account various factors that may influence the results, the only factor having a significant, independent effect on executive function was antidepressant treatment.
These findings, the authors conclude, suggest that antidepressant medication may have a role after stroke, regardless of whether or not the individual shows signs of depression.
SOURCE: British Journal of Psychiatry March 2007. 译文
http://www.reuters.com/article/healthNews/idUSWRI67887420070316
Antidepressant may boost brain function after stroke
抗抑郁药促进中风后脑功能的恢复
Fri Mar 16, 2007 5:55PM EDT
美国东部时间2007.3.16下午5:55
NEW YORK (Reuters Health) - Impaired cognitive function is common and often permanent following stroke. However, new study findings suggest that treatment with antidepressants may help stroke sufferers recover brain function and improve psychological and social capacities.
纽约（路透社健康新闻）中风后常见认知功能障碍，而且往往长久存在。然而，最新研究提示，抗抑郁药可能有助于中风患者脑功能的恢复，并且改善患者的心理与社会能力。
Dr. Sergio Paradiso and associates at the University of Iowa Carver College of Medicine in Iowa City studied 47 stroke patients being admitted to a rehabilitation center. They were randomly assigned to an older antidepressant called nortriptyline, the newer antidepressant Prozac, or inactive placebo.
爱荷华大学医学院的Sergio Paradiso博士及其同事对一个康复中心的47名中风患者进行了研究。这些患者被随即分配至老抗抑郁药去甲替林组、新抗抑郁药氟西汀组以及安慰剂组。
The patients were evaluated after 12 weeks of treatment and again 21 months later.
患者在治疗12周以及21个月后被分别进行评估。
The investigators observed no differences among the treatment groups in executive function (overall reasoning and functioning) at the first evaluation or in overall cognitive functioning at the 12- and 21-month evaluations.
研究者发现所有处置组中患者在首次评估中的执行功能（整体推理功能）方面、首次末次评估中整体认知功能方面并未显示差异。
However, at the final assessment, those given an antidepressant demonstrated marked improvement in executive function, independent of whether they were depressed.
然而，在末次评估中，服用抗抑郁药患者的执行功能得到显著的改善，而与患者是否有抑郁症无关。
In contrast, all but one of the placebo-treated patients had deteriorated significantly.
相对的是，安慰剂组一名患者出现了显著的恶化。
In the final analysis taking into account various factors that may influence the results, the only factor having a significant, independent effect on executive function was antidepressant treatment.
在最后的分析中考虑了多种可能影响结果的因素，唯一对执行功能具有显著的独立影响的因素是抗抑郁治疗。
These findings, the authors conclude, suggest that antidepressant medication may have a role after stroke, regardless of whether or not the individual shows signs of depression.
作者总结认为，这些研究结果提示，无论患者是否显示抑郁症状，抗抑郁治疗对于中风后治疗都可能具有重要作用。
SOURCE: British Journal of Psychiatry March 2007.
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作者:admin@医学,生命科学 2011-02-15 17:12
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