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【drug-news】肥胖新杀手——Boc5。
http://www.nature.com/nchina/2011/110202/full/nchina.2011.1.html
《自然》杂志网站近期发表了一篇报道如下：
肥胖新杀手
暴饮暴食、缺乏运动严重影响人们的身体健康，这一问题近些年也受到人们的关注，因为肥胖可以明显的增加糖尿病、心血管疾病及癌症患病率。
中科院上海药物研究所/药物筛选中心Mingwei Wang与美国处方药研究所的同道们共同发现了一种新复合物——Boc5，在糖尿病大鼠中研究发现Boc5可以刺激胰岛素分泌。提高胰岛素敏感性，降低血糖。在肥胖大鼠中研究证实，Boc5可以减轻肥胖大鼠的体重。
试验中用Boc5喂养肥胖大鼠共12周，每周3次。他们发现经Boc5治疗的肥胖大鼠体重、体重指数、食量及体内脂肪量明显减少。此外，体内胰岛素、瘦素、脂肪酸及胆固醇含量恢复正常。
实验显示Boc5通过一个复杂的协同机制作用于多种代谢疾病，利于疾病恢复，因此可能成为肥胖及糖尿病治疗的新手段。
原文如下：
Molecular biology: Fat has a new enemy
Felix Cheung
AbstractResearchers have discovered a compound that restores glucose homeostasis, reduces appetite and decreases body weight in obese mice
Original article citation
He, M. et al. Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice. PLoS ONE 5, e14205 (2010).
Introduction
? (2010) istockphoto.com/Sawayasu Tsuji
Overeating and under-exercising are causing more and more people to become obese every year. This trend is worrying because obesity significantly increases the risk of diabetes, cardiovascular diseases and cancer.
Mingwei Wang and co-workers at the National Center for Drug Screening and the Chinese Academy of Sciences in Shanghai, China, together with the Scripps Research Institute in USA, previously discovered a novel compound called Boc5 that reduces blood glucose, stimulates insulin secretion and elevates insulin sensitivity in diabetic mice. They have now tested Boc5 on obese mice and found that the compound also reduces body weight and fat.
The researchers fed Boc5 to diet-induced obese mice three times a week for 12 weeks. They found that after treatment, the obese mice had significantly reduced their body weight, body mass index, food intake and fat mass. In addition, insulin, leptin, fatty acid and cholesterol levels in obese mice all returned to normal.
The findings suggest that Boc5 restores a wide range of metabolic disorders through multiple synergistic mechanisms and offers an attractive tool for therapeutic intervention of obesity and diabetes.
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journal.pone.0014205.pdf (4870.27k) 在线查看 [标签:content2]
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作者:admin@医学,生命科学 2011-02-16 23:37
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