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【文摘发布】COPD患者6分钟步行距离变化的长期随
Authors: C. Casanova1,2, C. G. Cote3, J. M. Marin4, J. P. de Torres1, A. Aguirre-Jaime1, R. Mendez5, L. Dordelly3 and B. R. Celli6
Resource: Eur Respir J 2007; 29:535-540
The 6-min walking distance (6MWD) test is used in clinical practice and research into patients with chronic obstructive pulmonary disease (COPD). However, little is known about natural long-term change in this parameter.
The 6MWD was measured at baseline and then annually for 5 yrs in 294 patients with COPD and its annual rate of decline was determined. Forced expiratory volume in one second (FEV1) was also measured and the relationship between changes in both markers was explored.
At baseline, the median 6MWD was 380 m (range 160–600 m). It declined by 19% (16 m·yr-1) over the 5 yrs compared with baseline in patients with American Thoracic Society/European Respiratory Society stage III COPD (FEV1 30–50% predicted) and by 26% (15 m·yr-1) in patients with stage IV COPD (FEV1 <30% pred). Over the 5-yr follow-up, the proportion of patients with a minimal clinically significant decline of 54 m increased with the severity of the disease. It was 24% in stage II, 45% in stage III, and 63% in stage IV disease. In contrast, the rate of decline of FEV1 was greater in patients with milder airflow obstruction and lesser in patients with lower absolute FEV1 values.
In conclusion, the 6-min walking distance test provides increasingly useful information as the severity of chronic obstructive pulmonary disease increases. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title: The 6-min walking distance: long-term follow up in patients with COPD
标题： COPD患者6分钟步行距离变化的长期随访
Authors: C. Casanova1,2, C. G. Cote3, J. M. Marin4, J. P. de Torres1, A. Aguirre-Jaime1, R. Mendez5, L. Dordelly3 and B. R. Celli6
作者：C. Casanova1,2, C. G. Cote3, J. M. Marin4, J. P. de Torres1, A. Aguirre-Jaime1, R. Mendez5, L. Dordelly3 and B. R. Celli6
Resource: Eur Respir J 2007; 29:535-540
出处： Eur Respir J 2007; 29:535-540
The 6-min walking distance (6MWD) test is used in clinical practice and research into patients with chronic obstructive pulmonary disease (COPD). However, little is known about natural long-term change in this parameter.
临床上应用的6分钟步行距离(6MWD)试验（主要）用于对慢性阻塞性肺病(COPD)患者进行研究。但是，目前对此参数中的长期自然变化却还知之甚少。
The 6MWD was measured at baseline and then annually for 5 yrs in 294 patients with COPD and its annual rate of decline was determined. Forced expiratory volume in one second (FEV1) was also measured and the relationship between changes in both markers was explored.
本次研究包含294位COPD患者，分别测量其基线时和基线后连续5年的6MWD，并计算6MWD的年下降率。同时还测量一秒钟用力呼气量(FEV1)，并探讨这两个标记物变化之间的关系。
At baseline, the median 6MWD was 380 m (range 160–600 m). It declined by 19% (16 m•yr-1) over the 5 yrs compared with baseline in patients with American Thoracic Society/European Respiratory Society stage III COPD (FEV1 30–50% predicted) and by 26% (15 m•yr-1) in patients with stage IV COPD (FEV1 <30% pred). Over the 5-yr follow-up, the proportion of patients with a minimal clinically significant decline of 54 m increased with the severity of the disease. It was 24% in stage II, 45% in stage III, and 63% in stage IV disease. In contrast, the rate of decline of FEV1 was greater in patients with milder airflow obstruction and lesser in patients with lower absolute FEV1 values.
基线时的6MWD平均值是380m（160－600m范围）。（注：COPD分期参照美国胸科学会/欧洲呼吸学会所订标准）比较基线时与基线5年后的6MWD平均值，III 期COPD患者（FEV1预测值30–50%）的步行距离下降了19％(16 m•yr-1)，IV期 COPD患者(FEV1预测值 <30%)下降26％(15 m•yr-1)。有临床意义的最小步行下降距离是54m；在5年随访中，步行下降距离有临床意义的患者的比例随疾病严重度上升。该比例在COPDII期、III期、IV期患者中分别是24％、45％、63％。相比之下，在FEV1下降率方面，轻度气流阻塞患者的下降率更大，而 FEV1绝对值较低的患者的下降率则要小些。
In conclusion, the 6-min walking distance test provides increasingly useful information as the severity of chronic obstructive pulmonary disease increases.
结论：6分钟步行距离可为COPD严重度加重提供越来越有用的信息。 标题： COPD患者6分钟步行距离变化的长期随访
作者：C. Casanova1,2, C. G. Cote3, J. M. Marin4, J. P. de Torres1, A. Aguirre-Jaime1, R. Mendez5, L. Dordelly3 and B. R. Celli6
出处：Eur Respir J 2007; 29:535-540
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作者:admin@医学,生命科学 2011-01-15 17:14
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