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【medical-news】症状性颈动脉狭窄对侧显示炎性斑
症状性颈动脉狭窄对侧显示炎性斑块
NEW YORK (Reuters Health), Sep 15 - Patients with symptomatic carotid stenoses show evidence of considerable occult inflammation in contralateral carotid plaque, UK researchers report in the September issue of Stroke.
纽约（路透社健康版），9月15报道-------症状性颈动脉狭窄病人显示对侧颈动脉的隐匿性炎症斑块征象。英国研究者在9月份中风杂志上报道。
This paper, senior investigator Dr. Jonathan Gillard told Reuters Health, "has clinical implications regarding the management of carotid stenosis in that inflammatory burden assessment could be performed for improved risk stratification of individual patients."
高级研究员Jonathan Gillard在本研究中指出，本研究对于颈动脉狭窄的临床处理指导意义重大，这时因为对炎症程度的评估可以针对每一个病人进行风险评估。
Dr. Gillard of Cambridge University Hospitals NHS Foundation Trust and colleagues note that vulnerable atheromatous plaque is associated with inflammation, which can be detected by MRI using a contrast medium.
剑桥大学医院NHS研究基金Gillard博士领导下的研究小组指出，动脉硬化性脑病软斑块与炎症相关，采用增强MRI可以发现。
The team used ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI to explore signs of inflammation in 20 symptomatic patients.
该小组采用超微顺磁性铁氧化剂增强MRI研究有症状的20例病人的炎症。
Conventional angiography showed mean symptomatic stenosis of 77% compared with 46% on the asymptomatic side.
常规血管造影显示77%的病例具有症状侧的狭窄，46%具有非症状侧狭窄。
Inflammatory activity was seen in all symptomatic stenoses and inflammation was also seen in the contralateral side in all but one of the patients (95%).
症状性狭窄部位均可以见到活动性炎症，除了一例病人以外，其它均见到对侧的活动性炎症（95%）。
Signal loss after USPIO, an indicator of inflammatory activity, was noted in 71% of the 217 image quadrants on the symptomatic side versus 57% of 163 on the contralateral side, suggesting a bilateral inflammatory burden within the carotid atheromas.
代表活动性炎症的USPIO静脉注射后无信号，，可以见于病变侧217幅图像的71%，以及163例健侧图像的57%，提示颈动脉粥样硬化后双侧炎症。
This result, say the investigators, "adds weight to the argument that atherosclerosis is a truly systemic disease."
研究者补充说：“这一结果进一步了动脉粥样硬化是系统性疾病的观点。”
Dr. Gillard concluded, "Contralateral carotid stenosis should be followed up more closely as this sub-population of asymptomatic disease has a higher occult inflammatory burden."
Gillard总结说：“健侧颈动脉狭窄的病人需要更加密切随访，因为这一无症状性人群的炎症负荷更重”。
By David Douglas
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作者:admin@医学,生命科学 2010-12-10 17:11
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