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【medical-news】饮食中的抗氧化剂、蔬菜、水果与
Ai Kubo, M.P.H., Ph.D. 1 , Theodore R. Levin, M.D. 1 , Gladys Block, Ph.D. 2 , Gregory J. Rumore, M.D. 1 , Charles P. Quesenberry, Jr, Ph.D. 1 , Patricia Buffler, Ph.D. 2 , and Douglas A. Corley, M.D., Ph.D. 1,3
1 Division of Research, Kaiser Permanente, Oakland, California ; 2 School of Public Health, University of California, Berkeley, Berkeley, California ; and 3 Department of Medicine and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
Reprint requests and correspondence: Ai Kubo, Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612.
Copyright © 2008 American College of Gastroenterology/Blackwell Publishing
(Am J Gastroenterol 2008;103:1614–1623)
ABSTRACT
OBJECTIVE: The present study evaluated the associations among antioxidants, fruit and vegetable intake, and the risk of Barrett's esophagus (BE), a potential precursor to esophageal adenocarcinoma.
METHODS: We conducted a case–control study within the Kaiser Permanente Northern California population. Incident BE cases (N = 296) were matched to persons with gastroesophageal reflux disease (GERD) (GERD controls N = 308) and to population controls (N = 309). Nutrient intake was measured using a validated 110-item food frequency questionnaire. The antioxidant results were stratified by dietary versus total intake of antioxidants.
RESULTS: Comparing cases to population controls, dietary intake of vitamin C and beta-carotene were inversely associated with the risk of BE (4th vs 1st quartile, adjusted odds ratio [OR] 0.48, 95% confidence interval [CI] 0.26–0.90; OR 0.56, 95% CI 0.32–0.99, respectively), and the inverse association was strongest for vitamin E (OR 0.25, 95% CI 0.11–0.59). The inverse trends for antioxidant index (total and dietary) and fruit and vegetable intake were statistically significant, while most total intakes were not associated with reduced risk. The use of antioxidant supplements did not influence the risk of BE, and antioxidants and fruits and vegetables were inversely associated with a GERD diagnosis.
CONCLUSION: Dietary antioxidants, fruits, and vegetables are inversely associated with the risk of BE, while no association was observed for supplement intake. Our results suggest that fruits and vegetables themselves or associated undetected confounders may influence early events in the carcinogenesis of esophageal adenocarcinoma. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 ________________________________________
Dietary Antioxidants, Fruits, and Vegetables and the Risk of Barrett's Esophagus
饮食中抗氧化剂、水果和蔬菜与BE的关系。
ABSTRACT
摘要
OBJECTIVE: The present study evaluated the associations among antioxidants, fruit and vegetable intake, and the risk of Barrett's esophagus (BE), a potential precursor to esophageal adenocarcinoma.
目的：该研究评估了抗氧化剂、水果和蔬菜的摄入与患巴氏食管（BE）风险的关系，该病是食管腺癌的潜在病变。
METHODS: We conducted a case–control study within the Kaiser Permanente Northern California population. Incident BE cases (N = 296) were matched to persons with gastroesophageal reflux disease (GERD) (GERD controls N = 308) and to population controls (N = 309). Nutrient intake was measured using a validated 110-item food frequency questionnaire. The antioxidant results were stratified by dietary versus total intake of antioxidants.
方法：我们设计了一项在北加利福利亚人群中的病例对照研究。BE病例(N = 296)配对胃食管反流病病例(GERD N = 308)、对照组(N = 309)。抗氧化物结果通过食物分层，与总摄入量对比。
RESULTS: Comparing cases to population controls, dietary intake of vitamin C and beta-carotene were inversely associated with the risk of BE (4th vs 1st quartile, adjusted odds ratio [OR] 0.48, 95% confidence interval [CI] 0.26–0.90; OR 0.56, 95% CI 0.32–0.99, respectively), and the inverse association was strongest for vitamin E (OR 0.25, 95% CI 0.11–0.59). 结果：相对于对照组，饮食摄入维生素Ｃ和β -胡萝卜素与BE发生率负相关，而维生素Ｅ的负相关最强。The inverse trends for antioxidant index (total and dietary) and fruit and vegetable intake were statistically significant, while most total intakes were not associated with reduced risk. The use of antioxidant supplements did not influence the risk of BE, and antioxidants and fruits and vegetables were inversely associated with a GERD diagnosis.虽然大多数总摄入并不降低风险，抗氧化剂指数（总的和食谱的）和水果及蔬菜的摄入的负相关趋势有统计学差异。使用抗氧化剂补充并不影响BE发生风险，抗氧化剂和水果及蔬菜与GERD诊断负相关。
CONCLUSION: Dietary antioxidants, fruits, and vegetables are inversely associated with the risk of BE, while no association was observed for supplement intake. Our results suggest that fruits and vegetables themselves or associated undetected confounders may influence early events in the carcinogenesis of esophageal adenocarcinoma.结论：饮食中抗氧化剂、水果和蔬菜的摄入与BE风险负相关，然而添加摄入并不表现类似联系。我们的研究显示，水果、蔬菜本身或相关未经检测到的混合物可能影响食管腺癌早期的致癌阶段。
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作者:admin@医学,生命科学 2011-02-28 17:11
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