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【medical-news】在心肌纤维化中microRNA所扮演的角色
Key Words: microRNA • fibrosis • cardiac remodeling • heart failure • oligonucleotide-based therapy
An extract of the first 250 words of the full text is provided, because this article has no abstract.
Tissue fibrosis is a major cause of organ dysfunction in diseases of the cardiovascular, pulmonary, renal, and hepatic systems. Despite a relatively sophisticated understanding of the cell biological processes underlying fibrosis, there are few effective therapies, emphasizing the need for new insights into this disorder. A series of recent articles, including one by Creemers and colleagues in this issue of Circulation Research,1 reveal central roles for microRNAs (miRNAs) in the control of cardiac fibrosis and provide not only a new dimension to our understanding of this disease but also point to novel therapeutic opportunities. In addition, although most attention has been focused on abnormalities in cardiac myocytes that lead to cardiac dysfunction, these recent studies on the involvement of miRNAs in heart disease emphasize the importance of a much less understood cell type, the cardiac fibroblast, in pathological cardiac remodeling.
Fibrosis is a pathological feature common to numerous forms of heart disease, including myocardial infarction; ischemic, dilated, and hypertrophic cardiomyopathies; and heart failure. The cellular basis of fibrosis is the adverse accumulation of collagens and other extracellular matrix (ECM) proteins, which impairs ventricular function and predisposes the heart to arrhythmias.2,3 Transforming growth factor (TGF)-β, a potent stimulator of collagen production by cardiac fibroblasts, is induced in response to cardiovascular injury. Binding of TGF-β to its cell surface receptors activates the Smad pathway, which regulates the transcription of several key fibrotic genes, including those encoding connective tissue growth factor (CTGF), fibronectin, collagens, and plasminogen activator inhibitor-1.3 TGF-β reduces collagenase production . . .
Circulation Research. 2009;104:138 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-28 17:11
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