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【bio-news】Cell Stem Cell:日本科学家发现导致急性

据日本媒体8月8日报道,日本研究人员在最新出版的《细胞—干细胞》(Cell Stem Cell)杂志上发表报告说,他们发现了导致急性白血病复发的一个基因,如果能找到抑制该基因发挥作用的方法,就有可能防止急性白血病的复发。
急性白血病患者中有70%到80%的人都会复发。其原因是数量极少的白血病干细胞反复分裂,使白血病细胞大量增殖。抗癌药物虽然能够杀灭白血病细胞,但难以杀灭其中的白血病干细胞,造成急性白血病屡治屡发。东京大学教授黑川峰夫等人注意到,急性白血病复发患者体内的基因“Evi-1”在造血干细胞中非常活跃,他们推测这一基因可能同样作用于白血病干细胞,使其不断分裂,导致白血病细胞大量增殖。

研究小组从患白血病的实验鼠体内取出白血病细胞,去除了“Evi-1”基因后再移植到10只健康实验鼠体内。研究小组还给另外10只健康实验鼠完整移植了白血病细胞(含“Evi-1”)。结果发现,前一组实验鼠比后一组实验鼠平均晚发病一个月;而在杀灭两组实验鼠体内的白血病细胞后,前一组实验鼠没有复发急性白血病,后一组却再次发病。 (Bioon.com)

研究人员认为,对照实验已经说明,“Evi-1”对急性白血病的发作和复发有推动作用,而这与它作用于白血病干细胞有直接关系。

原始出处:

Cell Stem Cell,Vol 3, 207-220, 07 August 2008,usumu Goyama, Mineo Kurokawa

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

Susumu Goyama,1 Go Yamamoto,1 Munetake Shimabe,1 Tomohiko Sato,1 Motoshi Ichikawa,1 Seishi Ogawa,1,2,3 Shigeru Chiba,1,2 and Mineo Kurokawa1,

1 Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
2 Department of Cell Therapy and Transplantation Medicine, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
3 Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Corresponding author
Mineo Kurokawa
kurokawa-tky@umin.ac.jp

Summary

Evi-1 has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) in Evi-1-deficient embryos are severely reduced in number with defective proliferative and repopulating capacity. Selective ablation of Evi-1 in Tie2+ cells mimics Evi-1 deficiency, suggesting that Evi-1 function is required in Tie2+ hematopoietic stem/progenitors. Conditional deletion of Evi-1 in the adult hematopoietic system revealed that Evi-1-deficient bone marrow HSCs cannot maintain hematopoiesis and lose their repopulating ability. In contrast, Evi-1 is dispensable for blood cell lineage commitment. Evi-1+/− mice exhibit the intermediate phenotype for HSC activity, suggesting a gene dosage requirement for Evi-1. We further demonstrate that disruption of Evi-1 in transformed leukemic cells leads to significant loss of their proliferative activity both in vitro and in vivo. Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells.

(转自中国生物信息 ) 哇~
有意思,可他们是怎么发现Evi-1这个基因的呢
关于白血病细胞基因活动的研究已经不少了吧
可别人怎么没有先发现呢
谁能弄到全文?~ Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells.

只是说明 Evi-1是与干细胞的增殖和向白血病转化的一个关键调节因子,

从摘要没有说明与白血病的复发有关,只是与白血病的发病有关,完全不同的概念 cell stem cell
影响因子0

晕 群众的眼睛是雪亮的啊

看来“中国生物信息”的信息准确性有待考察,谁来翻译一下原文?把真实信息告诉大家! http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B8G3V-4T54T59-P&_user=10&_coverDate=08%2F07%2F2008&_rdoc=1&_fmt=high&_orig=browse&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f3cca8ac4501317082f25390f9429b1a

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作者:admin@医学,生命科学    2011-03-14 17:14
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