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【文摘发布】移植肾亚临床小管损伤的监测：尿
Author：Schaub S, Mayr M, Hönger G, Bestland J, Steiger J, Regeniter A, Mihatsch MJ, Wilkins JA, Rush D, Nickerson P.
Source：Transplantation. 2007 Jul 15;84(1):104-112.
BACKGROUND.: Tubulointerstitial injury due to rejection leads to tubular atrophy (TA)/interstitial fibrosis (IF) followed by deterioration of allograft function. This study investigated whether urinary tubular injury biomarkers can detect subclinical tubulitis found in protocol biopsies allowing for a noninvasive screening procedure. METHODS.: Four rigidly defined groups (stable transplants with normal tubular histology [n=24], stable transplants with subclinical tubulitis [n=38], patients with clinical tubulitis Ia/Ib [n=18], and patients with other clinical tubular pathologies [n=20]) were compared for differences in urinary intact/cleaved beta2-microglobulin (i/cbeta2m), retinol-binding protein (RBP), neutrophil-gelatinase-associated lipocalin (NGAL), and alpha1-microglobulin (alpha1m). RESULTS.: Tubular proteinuria was present in 38% (RBP) to 79% (alpha1m) of patients in the stable transplant with normal tubular histology group. The stable transplant with subclinical tubulitis group had slightly higher levels of i/cbeta2m (P=0.11), RBP (P=0.17), alpha1m (P=0.09), and NGAL (P=0.06) than the stable transplant with normal tubular histology group with a substantial overlap. The clinical tubulitis Ia/Ib and the other clinical tubular pathology groups had significantly higher levels of RBP, NGAL, and alpha1m than stable transplants with normal tubular histology or stable transplants with subclinical tubulitis (P<0.002). CONCLUSIONS.: None of the investigated biomarkers allow for clear differentiation between stable transplants with normal tubular histology and stable transplants with subclinical tubulitis. Therefore, the protocol allograft biopsy currently remains the preferred tool to screen for subclinical tubulitis. Further longitudinal studies should determine whether tubular proteinuria in stable transplants with normal tubular histology indicates a clear risk for early development of TA/IF. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 有些专业词汇不太了解，敬请指教：
初译：
Titlie：Detection of Subclinical Tubular Injury After Renal Transplantation: Comparison of Urine Protein Analysis With Allograft Histopathology.
移植肾亚临床小管损伤的监测：尿蛋白分析与移植肾病理比较
Author：Schaub S, Mayr M, Hönger G, Bestland J, Steiger J, Regeniter A, Mihatsch MJ, Wilkins JA, Rush D, Nickerson P.
Source：Transplantation. 2007 Jul 15;84(1):104-112.
BACKGROUND. Tubulointerstitial injury due to rejection leads to tubular atrophy (TA)/interstitial fibrosis (IF) followed by deterioration of allograft function. This study investigated whether urinary tubular injury biomarkers can detect subclinical tubulitis found in protocol biopsies allowing for a noninvasive screening procedure.
背景：由于排斥反应带来的小管间质损伤会导致小管萎缩（TA) /间质纤维化(IF)并使得移植肾功能恶化。这项研究探讨肾小管损伤的生物标记是否可在实验设计中检测出亚临床小管损伤从而考虑行无创性的筛查操作。 以下意见供参考：
BACKGROUND. Tubulointerstitial injury due to rejection leads to tubular atrophy (TA)/interstitial fibrosis (IF) followed by deterioration of allograft function. This study investigated whether urinary tubular injury biomarkers can detect subclinical tubulitis found in protocol biopsies allowing for a noninvasive screening procedure.
背景：由于排斥反应带来的小管间质损伤会导致小管萎缩（TA) /间质纤维化(IF)并使得移植肾功能恶化。这项研究探讨肾小管损伤的生物标记是否可在实验设计中检测出亚临床小管损伤从而考虑行无创性的筛查操作。[标签:content1][标签:content2]阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-13 05:11
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