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【medical-news】风湿性关节炎导致骨质疏松性骨折
NEW YORK (Reuters Health), Nov 2 - Patients with rheumatoid arthritis (RA) are at increased risk of fractures of the extremities, pelvis, and spine, as well as hip, even when they are not treated with glucocorticoids, results of a European study suggest.
The risks of osteoporosis and hip fracture are recognized complications of RA, the study authors indicate in their report, published in the October issue of Arthritis and Rheumatism. Still, little is known about how RA affects fracture risk at other sites, and whether the increased risk is due primarily to use of oral glucocorticoids or the underlying inflammatory disease.
Dr. Cyrus Cooper, from the University of Southampton in the U.K., and colleagues performed a large population-based study to more clearly elucidate the relationship between RA and fractures. They drew their data from the General Practice Research Database of the U.K. between 1987 and 2002. Each patient with RA was matched to three control patients without a history of RA, matched by age, gender, date, and practice.
Their cohort included roughly 30,000 patients with RA and 91,000 control subjects. During the study period, approximately 2,500 RA patients experienced a fracture. The relative risk (RR) of fracture was estimated after adjusting for BMI, smoking fracture and fall history, and treatment in the prior six months with bisphosphonates, hormone replacement therapy, and thiazides.
Patients with RA had an increased risk of fracture (RR = 1.5), particularly for the hip and spine but also for the pelvis, humerus, and tibia/fibula. The risk increased with the duration of the disease, and remained elevated after excluding patients who had been taking oral glucocorticoids.
Dr. Cooper's group concludes that "patients with RA are at a substantially increased risk of fractures at the hip, pelvis, vertebrae, humerus, and tibia/fibula." Independent risk factors were long-standing disease, low body mass index, and use of oral glucocorticoids. They maintain that disease activity and use of glucocorticoids were associated with similar magnitudes of effect.
Last Updated: 2006-11-01 12:34:21 -0400 (Reuters Health) Rheumatoid arthritis linked to increased risk of osteoporotic fracture
NEW YORK (Reuters Health), Nov 2 - Patients with rheumatoid arthritis (RA) are at increased risk of fractures of the extremities, pelvis, and spine, as well as hip, even when they are not treated with glucocorticoids, results of a European study suggest.
欧洲的研究人员称：类风湿病人即使不接受糖皮质激素治疗，发生肢体、骨盆、脊柱和骨盆骨折的风险性仍然增加。
The risks of osteoporosis and hip fracture are recognized complications of RA, the study authors indicate in their report, published in the October issue of Arthritis and Rheumatism. Still, little is known about how RA affects fracture risk at other sites, and whether the increased risk is due primarily to use of oral glucocorticoids or the underlying inflammatory disease.
关节10月份《关节炎与类风湿》杂志发表的文章：骨质酥松和骨盆骨折是风湿性关节炎常见并发症。但是关于风湿性关节炎与其它部位的骨折的关系，以及骨折风险性的增加是由于糖皮质激素还是由于炎症过程造成的问题不明确。
Dr. Cyrus Cooper, from the University of Southampton in the U.K., and colleagues performed a large population-based study to more clearly elucidate the relationship between RA and fractures. They drew their data from the General Practice Research Database of the U.K. between 1987 and 2002. Each patient with RA was matched to three control patients without a history of RA, matched by age, gender, date, and practice.
英国索桑普顿大学的Cyrus Cooper博士小组进行了大人群研究，清楚阐述了风湿性关节炎与骨折之间的关系。他们从大众实践研究数据库获得1987～2002的数据。每一例风湿性关节炎病人由于无风湿性关节炎的三个对照组病人进行年龄、性别和运动的配对。
Their cohort included roughly 30,000 patients with RA and 91,000 control subjects. During the study period, approximately 2,500 RA patients experienced a fracture. The relative risk (RR) of fracture was estimated after adjusting for BMI, smoking fracture and fall history, and treatment in the prior six months with bisphosphonates, hormone replacement therapy, and thiazides.
这一队列包括3万名RA病人和九万一千名对照组。在研究期间，大约2500名RA病人发生骨折，根据BMI校正之后的相对危险因素未：吸烟，骨折，跌落病史，二磷酸盐治疗，激素治疗和噻嗪类治疗。
Patients with RA had an increased risk of fracture (RR = 1.5), particularly for the hip and spine but also for the pelvis, humerus, and tibia/fibula. The risk increased with the duration of the disease, and remained elevated after excluding patients who had been taking oral glucocorticoids.
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作者:admin@医学,生命科学 2011-03-06 05:16
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