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【medical-news】原发性胆汁性肝硬化患者的骨折风
NEW YORK (Reuters Health) Jan 29 - Patients with primary biliary cirrhosis have a slightly increased risk of fracture compared to the general population, according to researchers in the UK.
"Controversy exists as to whether people with primary biliary cirrhosis (PBC) have an increased risk of developing osteoporosis and the extent to which this may translate into an increased risk of fracture," Dr. Joe West from the University of Nottingham and colleagues write in the December issue of Gastroenterology.
Using the General Practice Research Database, the researchers conducted a cohort study involving 930 subjects with PBC and 9202 age- and sex-matched controls.
Among the subjects with PBC, there were 137 recorded incident fractures of any type, 25 incident hip fractures, and 44 incident ulna/radius fractures. The overall rates of any fracture for the PBC and control groups were 258 and 133 per 10,000 person-years, respectively. The hazard ratio for fractures of any type was 2.04 for the PBC cohort compared with the control group. For hip and ulna/radius fractures, the HRs were 2.14 and 1.95, respectively.
"The absolute excess in fracture rates were for any fracture 12.5 per 1000 person-years, for hip fracture 1.9 per 1000 person-years, and for ulna/radius fracture 3.4 per 1000 person-years," Dr. West and colleagues report.
"The relative increases might suggest that interventions to prevent fracture in people with PBC are appropriate," the team comments, "yet the absolute increases indicate that only small reductions in fracture occurrence would be expected."
Gastroenterology 2006;131:1752-1757.
http://www.medscape.com/viewarticle/551426 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Fracture Risk Increased in Primary Biliary Cirrhosis
原发性胆汁性肝硬化患者的骨折风险增加
NEW YORK (Reuters Health) Jan 29 - Patients with primary biliary cirrhosis have a slightly increased risk of fracture compared to the general population, according to researchers in the UK.
纽约时报(路透社健康消息)1月29日-根据英国研究者的说法,同一般的人群相比有原发性胆汁性肝硬化的患者可能会轻度增加骨折的风险.
"Controversy exists as to whether people with primary biliary cirrhosis (PBC) have an increased risk of developing osteoporosis and the extent to which this may translate into an increased risk of fracture," Dr. Joe West from the University of Nottingham and colleagues write in the December issue of Gastroenterology.
来自诺丁汉大学的Joe West医生和他的同事在12月号的《胃肠道杂志》上写道，“一直存在着就是否患有原发性胆汁性肝硬化（PBC）会增加骨质疏松的风险的和它会转化成骨折风险的程度的争论。”
Using the General Practice Research Database, the researchers conducted a cohort study involving 930 subjects with PBC and 9202 age- and sex-matched controls.
通过使用综合医疗研究数据库，研究者们指导了一个包括930名患有PBC
Among the subjects with PBC, there were 137 recorded incident fractures of any type, 25 incident hip fractures, and 44 incident ulna/radius fractures. The overall rates of any fracture for the PBC and control groups were 258 and 133 per 10,000 person-years, respectively. The hazard ratio for fractures of any type was 2.04 for the PBC cohort compared with the control group. For hip and ulna/radius fractures, the HRs were 2.14 and 1.95, respectively.
在哪些PBC的患者中，有137人发生过某种形式骨折记录，25人髋骨折还有44人有过尺骨和桡骨骨折。对于PBC患者任何形式的骨折和对照组的总体概率每年在10000人中分别是258人和133人。对于尺骨和桡骨骨折HRs 值分别是2.14和1.95。
"The absolute excess in fracture rates were for any fracture 12.5 per 1000 person-years, for hip fracture 1.9 per 1000 person-years, and for ulna/radius fracture 3.4 per 1000 person-years," Dr. West and colleagues report.
West医生和他的同事说，“这是绝对过剩的骨折率对于每年1000个人中有12.5人有骨折，1.9个人有髋骨折3.4个人有桡骨折的概率来说。”
"The relative increases might suggest that interventions to prevent fracture in people with PBC are appropriate," the team comments, "yet the absolute increases indicate that only small reductions in fracture occurrence would be expected."
这个小组评论到，“相对增加或许暗示了阻止患有PBC人的骨折是恰当的，然而绝对的增加表明我们只有期待骨折发生数量少量减少。
Gastroenterology 2006;131:1752-1757.
原发性胆汁性肝硬化患者的骨折风险增加
纽约时报(路透社健康消息)1月29日-根据英国研究者的说法,同一般的人群相比有原发性胆汁性肝硬化的患者可能会轻度增加骨折的风险.
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作者:admin@医学,生命科学 2011-03-13 17:12
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