主页 > 医药生命 >
【medical-news】基因变异组合使心衰风险加倍
29 January 2007
The angiotensin (AGT) gene polymorphisms M235T and T174M are associated with mortality in heart failure (HF) patients, New Zealand researchers report.
Furthermore, by combining "high-risk" genotypes, namely the 235TT allele and at least one 174M allele, the team identified a subgroup of patients who have a two-fold greater risk of dying during follow-up after admission with HF than those with "low-risk" genotype combinations.
Noting that these two polymorphisms have been linked individually with increased plasma angiotensinogen levels, hypertension, and left ventricular hypertrophy, the team genotyped 451 HF patients for each, and looked for any associations with survival and prognostic hormone markers.
Patients carrying one or more 174M allele more frequently had a history of HF compared with 174TT homozygotes, and had increased mortality during follow-up, with a risk ratio of 1.69 (p=0.038), despite having higher left ventricular ejection fractions (p=0.009).
Furthermore, patients with high-risk genotype combinations, defined as the combination of 235TT and/or at least one 174M allele had a two-fold greater risk of dying during the follow-up period than those carrying low-risk genotypes (235MM or MT in combination with 174TT; risk ratio=2.0).
High-risk patients were more likely to have a history of HF (38% vs 29%) and had a higher left ventricular mass index (341 vs 308 g/m2), as well as being on average 2 years younger, and less likely to be treated with beta blockers.
But the high-risk combinations predicted mortality independently of established risk factors, including age, gender, ethnicity, previous history of HF or myocardial infarction, left ventricular ejection fraction, renal dysfunction, beta-blocker and spironolatone treatment, and plasma brain natriuretic peptide and AGT II levels.
The proportion of deaths in the cohort that could be attributed to the presence of high-risk genotypes was estimated at 24%.
"AGT variants M235T and T174M were independently predictive of mortality in HF patients and may provide additional prognostic information in the clinical setting," conclude the authors.
Hypertension 2007; 49: 322–327
http://www.incirculation.net/NewsItem/Gene-variant-combination-doubles-heart-failure-ris.aspx 我认领这个,48小时没搞完，请各位战友自由认领 今天没事,早点交作业
请各位战友多指教
Gene variant combination doubles heart failure risk
基因变异型结合加倍了心力衰竭的危险
29 January 2007
The angiotensin (AGT) gene polymorphisms M235T and T174M are associated with mortality in heart failure (HF) patients, New Zealand researchers report.
新西兰科学家报道：他们发现血管紧张素（AGT）多基因型M235T和T174M与心力衰竭患者的死亡率有密切关系。
Furthermore, by combining "high-risk" genotypes, namely the 235TT allele and at least one 174M allele, the team identified a subgroup of patients who have a two-fold greater risk of dying during follow-up after admission with HF than those with "low-risk" genotype combinations.
而且，通过研究具有“高危”基因型如：235TT和至少1个174M等位基因的患者，研究小组发现他们患上心力衰竭的死亡率是“低危”基因型的2倍。
Noting that these two polymorphisms have been linked individually with increased plasma angiotensinogen levels, hypertension, and left ventricular hypertrophy, the team genotyped 451 HF patients for each, and looked for any associations with survival and prognostic hormone markers.
研究小组通过分析451位心力衰竭患者的基因型，研究了所有幸存者及他们体内激素标记之间的对应关系，他们发现，两种多基因型与血管紧张素水平升高，高血压以及左心室肥大没有确切联系。
Patients carrying one or more 174M allele more frequently had a history of HF compared with 174TT homozygotes, and had increased mortality during follow-up, with a risk ratio of 1.69 (p=0.038), despite having higher left ventricular ejection fractions (p=0.009).
具有一个或多个174M等位基因的患者与具有174TT结合子的患者相比，不论他们的左心室供血能力如何，都更容易发生心力衰竭，并且死亡率更高，死亡率大约1.69（p＝0.038）。
Furthermore, patients with high-risk genotype combinations, defined as the combination of 235TT and/or at least one 174M allele had a two-fold greater risk of dying during the follow-up period than those carrying low-risk genotypes (235MM or MT in combination with 174TT; risk ratio=2.0).
此外，具有多个高危基因型结合的患者，如有235TT和至少1个174M等位基因结合，他们心力衰竭后的死亡率是具有低危基因型的两倍。（235MM或MT与174TT结合，死亡率＝2.0）
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-11 17:15
医学,生命科学网