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【medical-news】服用阿司匹林降低哮喘风险
WASHINGTON (Reuters) - People who take aspirin regularly can reduce their risk of asthma, U.S. researchers reported on Wednesday.
They found women who took a small dose of aspirin -- 100 mg every other day -- were 10 percent less likely to develop asthma over 10 years than women given placebos.
Writing in the journal Thorax, the researchers said their findings reinforce studies that show men who took aspirin daily were less likely to develop asthma, too.
"Although aspirin can worsen symptoms in some patients with asthma, our biologically plausible finding long with similar results from a large randomized trial in men and observational cohort studies in women suggests a small benefit of aspirin for the prevention of the development of asthma in adults," wrote Dr. Tobias Kurth and colleagues of Brigham and Women's Hospital and Harvard Medical School in Boston.
"However, before public recommendations are provided, results from randomized trials are needed that are specifically designed to test whether low-dose aspirin reduces the risk of asthma," they added.
Kurth's team studied 37,000 female healthcare professionals taking part in a study called the Women's Health Study. All were aged 45 and above, and had no serious illness, allergy or asthma at the start of the study.
They were randomly assigned to take 100 mg of aspirin every other day, or a dummy tablet.
Among the women who got real aspirin, 872 developed asthma over the 10 years, compared to 963 taking the placebo.
Women who were obese, with a body mass index of 30 or above, got no benefit from aspirin, they noted.
"The effect of aspirin on adult-onset asthma was not significantly modified by age, smoking status, exercise levels, postmenopausal hormone use or randomized vitamin E assignment," they added.
Aspirin can affect compounds involved in inflammation and the hyper-response of airways that is seen in asthma.
The researchers noted that between 4 percent and 11 percent of patients with asthma have an acute response to aspirin.
http://www.reuters.com/article/healthNews/idUSN1223488620080312
screen.width-333)this.width=screen.width-333" width=241 height=340 title="Click to view full F200611150911322229827943.jpg (241 X 340)" border=0 align=absmiddle> 研究发现服用阿司匹林可以预防哮喘
华盛顿（路透社）美研究人员在周三报道说，人们规律地服用阿司匹林可以降低哮喘的发病危险。
他们发现女性服用小剂量阿司匹林--隔日100mg--十年以上发生哮喘的可能性比服用安慰剂者降低10%。
在胸科杂志上，研究者们写到，他们的发现也印证了关于男性每日服用阿司匹林可以减少哮喘发病的可能性的研究。
Brigham大学、女子医院、波士顿哈佛医学院和Dr. Tobias Kurth写到，“尽管阿司匹林可以使某些哮喘病人的症状加重，但我们在生物学上合理的发现，和来自对男性的一个大型随机试验以及对女性的观测群组研究的相似结论，都表明阿司匹林对成人哮喘的预防有一点好处。”
他们补充道：“然而在给出公众推荐之前，我们需要对小剂量的阿司匹林能否降低哮喘的风险进行的专门设计的随机试验的结果。”
Kurth的团队研究了37000名参加女性健康研究的女性医疗保健专业人才，她们都在45岁以上，且在研究开始时没有严重疾病、过敏或哮喘史。
她们被随机分为两组，一组隔日服用100mg阿司匹林，对照组服用安慰剂药片。10年以后，服用阿司匹林组有872人发生了哮喘，而对照组963人发生了哮喘。
他们指出，体重指数≥30的肥胖妇女不能从阿司匹林中获益。
他们补充道“阿司匹林对成年起病哮喘的作用受年龄、吸烟状况、活动情况、绝经后激素替代、随机服用维生素E的影响并不大。”
阿司匹林可以影响炎症时涉及的（炎性）复合物和哮喘者存在的气道高反应性。
研究人员称4%-11%的哮喘病人对阿司匹林有急性反应。
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作者:admin@医学,生命科学 2011-02-09 17:14
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