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【文摘发布】Nogo蛋白及其受体在小鼠胚胎视路中
Wang J, Chan CK, Taylor JS, Chan SO.
J Neurosci Res. 2008 Jan 23
We have investigated the localization of Nogo, an inhibitory protein acting on regenerating axons in the adult central nervous system, in the embryonic mouse retinofugal pathway during the major period of axon growth into the optic chiasm. In the retina, Nogo protein was localized on the neuroepithelial cells at E12 and at later stages (E13-E17) on radial glial cells. Colocalization studies showed expression of Nogo on vimentin-positive glia in the retina and at the optic nerve head but not on most of the TuJ1- and islet-1-immunoreactive neurons. Only a few immature neurons in the ventricular and peripheral regions of the E13 retina were immunoreactive to Nogo. In the ventral diencephalon, Nogo was expressed on radial glia, most strongly on the dense radial glial midline raphe within the chiasm where uncrossed axons turn and in the initial segment of the optic tract. In vitro studies showed that the Nogo receptor (NgR) was expressed on the neurites and growth cones from both the ventral temporal and dorsal nasal quadrant of the retina. In the optic pathway, NgR staining was obvious in the vitreal regions of the retina and on axons in the optic stalk and the optic tract, but not in the chiasm. These expression patterns suggest an interaction of Nogo with its receptor in the mouse retinofugal pathway, which may be involved in guiding axons into the optic pathway and in governing the routing of axons in the optic chiasm. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Localization of Nogo and its receptor in the optic pathway of mouse embryos.
Wang J, Chan CK, Taylor JS, Chan SO.
J Neurosci Res. 2008 Jan 23
We have investigated the localization of Nogo, an inhibitory protein acting on regenerating axons in the adult central nervous system, in the embryonic mouse retinofugal pathway during the major period of axon growth into the optic chiasm.
我们在胚胎小鼠轴突生长对旺盛的时间对于小鼠视神经通路的视交叉上的Nogo蛋白的分布进行了研究，这种蛋白是一种作用于成年个体的中枢神经系统轴突再生的抑制性蛋白。
In the retina, Nogo protein was localized on the neuroepithelial cells at E12 and at later stages (E13-E17) on radial glial cells. Colocalization studies showed expression of Nogo on vimentin-positive glia in the retina and at the optic nerve head but not on most of the TuJ1- and islet-1-immunoreactive neurons.
在12天甚至更晚的时候（13-17天），Nogo蛋白分部在神经上皮细胞中的放射状胶质细胞中。共区域化的研究显示Nogo在视网膜和视神经上弹性蛋白阳性的胶质细胞中表达，但在TuJ1-和islet-1的免疫反应细胞中却不表达
Only a few immature neurons in the ventricular and peripheral regions of the E13 retina were immunoreactive to Nogo.
在13天的视网膜上，只有在室部和外周部的一小部分的未成熟的神经元对于Nogo有免疫反应。
In the ventral diencephalon, Nogo was expressed on radial glia, most strongly on the dense radial glial midline raphe within the chiasm where uncrossed axons turn and in the initial segment of the optic tract.
在腹侧间脑中，Nogo在放射状的胶质细胞中表达，特别是那些在未交叉的轴突会转动的视交叉里的密集放射状的胶质细胞中和视束的轴突始段
In vitro studies showed that the Nogo receptor (NgR) was expressed on the neurites and growth cones from both the ventral temporal and dorsal nasal quadrant of the retina.
体外实验表明Nogo受体（NgR）在视网膜的腹颞侧和背鼻侧的神经突起和生长锥中表达。
In the optic pathway, NgR staining was obvious in the vitreal regions of the retina and on axons in the optic stalk and the optic tract, but not in the chiasm.
在视觉传导通路上，NgR染色明显地显示这些受体在视网膜的玻璃体接触部位，眼柄和视束的轴突部位，但并不早视交叉上
These expression patterns suggest an interaction of Nogo with its receptor in the mouse retinofugal pathway, which may be involved in guiding axons into the optic pathway and in governing the routing of axons in the optic chiasm.
这种表达方式提示了Nogo和其受体在小鼠视觉通路上的表达是有相互作用的，这种相互作用可能包含了引导轴突进入视觉通路和控制常规的轴突进入视交叉。
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这是我第一次翻译，错误很多，请大家指教,谢谢 多谢你的参与，希望经常来喔！ [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-14 17:14
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