主页 > 医药科学 >
【medical-news】舒张性心力衰竭患者普遍存在心脏
NEW YORK (Reuters Health) Jan 25 - Both systolic and diastolic dyssynchrony occur frequently in patients with diastolic heart failure, according to a study conducted at The Methodist Hospital in Houston.
Treatment of dyssynchrony shortens the diastolic intraventricular time delay and improves left ventricular relaxation, Dr. Sherif F. Nagueh and his associates report in the Journal of the American College of Cardiology for January 2/9.
There has been little examination of the prevalence or effects of dyssynchrony in patients with diastolic heart failure and normal ejection fraction, the authors note, and there are no published data on the effects of therapy on dyssynchrony.
They therefor conducted hemodynamic and echocardiographic studies on three groups of patients matched by age and gender: 60 patients with diastolic heart failure and ejection fraction of 50% or higher, 60 patients with systolic heart failure with ejection fraction of less than 50%, and 35 controls.
Systolic dyssynchrony was present in 33% of patients with diastolic heart failure and 40% of those with systolic heart failure.
In contrast, diastolic dyssynchrony was present in 58% of those with diastolic heart failure and in 60% of those with systolic heart failure.
Compared with controls, the patients had higher left ventricular mass, left atrial volume index, and pulmonary artery systolic pressure. Tissue Doppler also showed longer systolic and diastolic intraventricular delays in the heart failure patients.
Medications, including diuretics, beta-blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors, and/or angiotensin-receptor blockers, decreased blood pressure and left ventricular filling pressures and improved left ventricular relaxation. However, ejection fraction and left atrial volume index stayed the same.
Biventricular pacing is beneficial in patients with systolic heart failure, but it is unknown how it would affect patients with diastolic heart failure, the researchers point out.
"However," they conclude, "it may be beneficial, similar to the observations in those with depressed ejection fraction, to some but not all patients, given the multiple etiologies of diastolic dyssynchrony in patients with diastolic heart failure."
J Am Coll Cardiol 2007;49:88-96.
http://www.medscape.com/viewarticle/551294 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
Dyssynchrony Common in Diastolic Heart Failure
舒张性心力衰竭患者普遍存在心脏运动不同步
NEW YORK (Reuters Health) Jan 25 - Both systolic and diastolic dyssynchrony occur frequently in patients with diastolic heart failure, according to a study conducted at The Methodist Hospital in Houston.
纽约路透社1月25日报道: 根据休斯顿一家美以美教派医院的研究，舒张期心衰普遍存在着收缩期、舒张期心脏运动的不同步现象。
Treatment of dyssynchrony shortens the diastolic intraventricular time delay and improves left ventricular relaxation, Dr. Sherif F. Nagueh and his associates report in the Journal of the American College of Cardiology for January 2/9.
Sherif F. Nagueh博士和他的同事在1月份的美国心脏病学会上报告说，对心脏不同步的治疗缩短了舒张期心室内的时间延迟，从而改善了左心室的舒张。
There has been little examination of the prevalence or effects of dyssynchrony in patients with diastolic heart failure and normal ejection fraction, the authors note, and there are no published data on the effects of therapy on dyssynchrony.
作者介绍，迄今为止，关于舒张期心衰及正常射血分数的病人心脏运动不同步的患病率及效应的调查还很少，其治疗的效果也没有公开发表的数据支持。
They therefor conducted hemodynamic and echocardiographic studies on three groups of patients matched by age and gender: 60 patients with diastolic heart failure and ejection fraction of 50% or higher, 60 patients with systolic heart failure with ejection fraction of less than 50%, and 35 controls.
因此，他们对三组病人进行了一项血液动力学及超声心动图的研究，60例是舒张期心衰，射血分数在50％或以上的；60例是收缩期心衰，射血分数是50％以下的；35例作为对照。
Systolic dyssynchrony was present in 33% of patients with diastolic heart failure and 40% of those with systolic heart failure.
收缩期心脏运动不同步在舒张期心衰病人中出现率是33％，在收缩期是40％。
In contrast, diastolic dyssynchrony was present in 58% of those with diastolic heart failure and in 60% of those with systolic heart failure.
相反地，舒张期心脏运动不同步在舒张期心衰病人中出现率是58％，在收缩期是60％。
Compared with controls, the patients had higher left ventricular mass, left atrial volume index, and pulmonary artery systolic pressure. Tissue Doppler also showed longer systolic and diastolic intraventricular delays in the heart failure patients.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-13 05:14
医学,生命科学网