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【文摘发布】直肠癌术后放射治疗增加术后小肠
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Titleostoperative Irradiation for Rectal Cancer Increases the Risk of Small Bowel Obstruction After Surgery
Author: Nancy N. Baxter, Lacey K. Hartman, Joel E. Tepper, Rocco Ricciardi, Sara B. Durham, and Beth A. Virnig
Source: Ann Surg. 2007 ; 245(4):553-559
Abstract:
OBJECTIVE: To determine the risk of small bowel obstruction (SBO) after irradiation (RT) for rectal cancer BACKGROUND:: SBO is a frequent complication after standard resection of rectal cancer. Although the use of RT is increasing, the effect of RT on risk of SBO is unknown. METHODS: We conducted a retrospective cohort study using Surveillance, Epidemiology, and End Results cancer registry data linked to Medicare claims data to determine the effect of RT on risk of SBO. Patients 65 years of age and older diagnosed with nonmetastatic invasive rectal cancer treated with standard resection from 1986 through 1999 were included. We determined whether patients had undergone RT and evaluated the effect of RT and timing of RT on the incidence of admission to hospital for SBO, adjusting for potential confounders using a proportional hazards model. RESULTS: We identified a total of 5606 patients who met our selection criteria: 1994 (36%) underwent RT, 74% postoperatively. Patients were followed for a mean of 3.8 years. A total of 614 patients were admitted for SBO over the study period; 15% of patients in the RT group and 9% of patients in the nonirradiated group (P < 0.001). After controlling for age, sex, race, diagnosis year, type of surgery, and stage, we found that patients who underwent postoperative RT were at higher risk of SBO, hazard ratio 1.69 (95% CI, 1.3-2.1). However, the long-term risk associated with preoperative irradiation was not statistically significant (hazard ratio, 0.89; 95% CI, 0.55-1.46). CONCLUSIONS: Postoperative but not preoperative RT after standard resection of rectal cancer results in an increased risk of SBO over time. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 。 Title：Postoperative Irradiation for Rectal Cancer Increases the Risk of Small Bowel Obstruction After Surgery
题目：直肠癌术后放射治疗增加术后小肠梗阻的风险
Author: Nancy N. Baxter, Lacey K. Hartman, Joel E. Tepper, Rocco Ricciardi, Sara B. Durham, and Beth A. Virnig
作者：: Nancy N. Baxter, Lacey K. Hartman, Joel E. Tepper, Rocco Ricciardi, Sara B. Durham, Beth A. Virnig
Source: Ann Surg. 2007 ; 245(4):553-559
出处：《外科学年鉴》杂志 2007 ; 245(4):553-559
Abstract:
OBJECTIVE: To determine the risk of small bowel obstruction (SBO) after irradiation (RT) for rectal cancer
摘要：
目的：判定直肠癌放射治疗（irradiation, RT）后致小肠梗阻（small bowel obstruction, SBO）的风险。
BACKGROUND: SBO is a frequent complication after standard resection of rectal cancer. Although the use of RT is increasing, the effect of RT on risk of SBO is unknown.
背景：SBO是直肠癌根治术后的一种常见并发症。虽然放射治疗的应用越来越普及，但RT引发SBO的风险尚未明确。
METHODS: We conducted a retrospective cohort study using Surveillance, Epidemiology, and End Results cancer registry data linked to Medicare claims data to determine the effect of RT on risk of SBO. Patients 65 years of age and older diagnosed with nonmetastatic invasive rectal cancer treated with standard resection from 1986 through 1999 were included.
方法：我们利用与医疗保险索赔数据有关的癌症监测、流行病学、最终结果登记资料，进行了一次回顾性群组研究来判定RT导致SBO的风险。本研究选择1986年至1999年间，年龄≥65岁，患未转移的浸润性直肠癌并行标准根治术治疗的患者为研究对象。
We determined whether patients had undergone RT and evaluated the effect of RT and timing of RT on the incidence of admission to hospital for SBO, adjusting for potential confounders using a proportional hazards model.
我们根据患者是否接受过RT来评估RT和RT时程对SBO入院率的影响，并应用比例危险率模型对潜在的混杂变量进行校正。
RESULTS: We identified a total of 5606 patients who met our selection criteria: 1994 (36%) underwent RT, 74% postoperatively. Patients were followed for a mean of 3.8 years. A total of 614 patients were admitted for SBO over the study period; 15% of patients in the RT group and 9% of patients in the nonirradiated group (P < 0.001).
结果：我们纳入了总共5606例符合我们筛选标准的患者：1994例（36%）患者进行了RT，其中有74%的患者术后进行RT。平均随访3.8年。研究期间，总共有614名患者因 SBO收治入院；其中RT组的患者占15%，非放疗组的患者占9%（P<0.001）。
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作者:admin@医学,生命科学 2011-03-14 05:11
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