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【文摘发布】按照绝经时年龄与绝经年限分析绝
Author：Jacques E. Rossouw, MD; Ross L. Prentice, PhD; JoAnn E. Manson, MD, DrPH; LieLing Wu, MSc; David Barad, MD; Vanessa M. Barnabei, MD, PhD; Marcia Ko, MD; Andrea Z. LaCroix, PhD; Karen L. Margolis, MD; Marcia L. Stefanick, PhD
Resource: JAMA. 2007;297:1465-1477.
Abstract：
Context Title：Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause
标题：按照绝经时年龄与绝经年限分析绝经后激素治疗与患心血管疾病危险性间的相关性
作者：Jacques E. Rossouw, MD; Ross L. Prentice, PhD; JoAnn E. Manson, MD, DrPH; LieLing Wu, MSc; David Barad, MD; Vanessa M. Barnabei, MD, PhD; Marcia Ko, MD; Andrea Z. LaCroix, PhD; Karen L. Margolis, MD; Marcia L. Stefanick, PhD
来源: JAMA. 2007;297:1465-1477.
Abstract：
摘要：
Context ：The timing of initiation of hormone therapy may influence its effect on cardiovascular disease.
内容：激素治疗起始时间可能影响其对心血管病的作用。
Objective： To explore whether the effects of hormone therapy on risk of cardiovascular disease vary by age or years since menopause began.
目的：研究激素治疗对心血管病风险的影响是否随绝经年龄或绝经后年限变化。
Design, Setting, and Participants ：Secondary analysis of the Women's Health Initiative (WHI) randomized controlled trials of hormone therapy in which 10 739 postmenopausal women who had undergone a hysterectomy were randomized to conjugated equine estrogens (CEE) or placebo and 16 608 postmenopausal women who had not had a hysterectomy were randomized to CEE plus medroxyprogesterone acetate (CEE + MPA) or placebo. Women aged 50 to 79 years were recruited to the study from 40 US clinical centers between September 1993 and October 1998.
设计、设置、参加人员：二级分析美国妇女健康研究（WHI）激素疗法随机对照试验，其中10739例已行子宫全切术的绝经妇女随机分配至结合型雌激素组（CEE）或安慰剂组，166608例未行子宫全切术的绝经妇女随机分配至CEE联合安宫黄体酮组或安慰剂组。1993年9月到1998年10月间来自美国40个临床中心50至70岁妇女参加了该研究。
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作者:admin@医学,生命科学 2011-04-25 17:16
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