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【文摘发布】腹主动脉钙化能够预测血透患者的
Okuno S, Ishimura E, Kitatani K, Fujino Y, Kohno K, Maeno Y, Maekawa K, Yamakawa T, Imanishi Y, Inaba M, Nishizawa Y.
Am J Kidney Dis. 2007 Mar;49(3):417-25.
BACKGROUND: Although abdominal aortic calcification (AAC) is reported as a predictor for cardiovascular mortality in the general population, it is unknown whether this is also true in hemodialysis patients in whom vascular calcification and cardiovascular diseases are highly prevalent. STUDY DESIGN: Cohort study. SETTINGS & PARTICIPANTS: 515 patients on maintenance hemodialysis therapy at a single center. PREDICTOR: AAC evaluated in a plain roentgenograph of the lateral abdomen at baseline. OUTCOMES & MEASUREMENTS: All-cause and cardiovascular death. RESULTS: Mean age was 60 +/- 12 (SD) years. AAC was present in 291 patients (56.5%). During a mean follow-up period of 51 +/- 17 months, there were 103 all-cause deaths, of which 41 were from cardiovascular diseases. Of patients with and without AAC, 27.8% and 9.8% died, respectively (11.6% and 3.1% of cardiovascular diseases, respectively). Kaplan-Meier analysis showed that all-cause mortality was significantly greater in patients with AAC compared to those without (P < 0.0001, log-rank test). Similarly, cardiovascular mortality was significantly greater in the former than in the latter group (P = 0.0001, log-rank test). Multivariate Cox proportional hazards analysis found that the presence of AAC was significantly associated with increased all-cause mortality (hazard ratio, 2.07; 95% confidence interval, 1.21 to 3.56; P < 0.01) and increased cardiovascular mortality (hazard ratio, 2.39; 95% confidence interval, 1.01 to 5.66; P < 0.05) after adjustment for age, hemodialysis duration, presence of diabetes, serum albumin level, and C-reactive protein level. LIMITATIONS: Nonquantitative assessment of AAC and the lack of information for medication and history of cardiovascular diseases. CONCLUSION: The presence of AAC is significantly associated with both all-cause and cardiovascular mortality in hemodialysis patients, suggesting that careful attention should be given to the presence of AAC in a simple radiograph of the lateral abdomen as a prognostic indicator. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Presence of abdominal aortic calcification is significantly associated with all-cause and
cardiovascular mortality in maintenance hemodialysis patients.
持续性血透患者腹主动脉钙化与全因死亡率和心血管死亡率显著关联
Okuno S, Ishimura E, Kitatani K, Fujino Y, Kohno K, Maeno Y, Maekawa K, Yamakawa T, Imanishi Y, Inaba M, Nishizawa Y.
Am J Kidney Dis. 2007 Mar;49(3):417-25.
美国肾脏病杂志 2007年3月49卷3期 页码417-425
BACKGROUND: Although abdominal aortic calcification (AAC) is reported as a predictor for cardiovascular mortality in the general population, it is unknown whether this is also true in hemodialysis patients in whom vascular calcification and cardiovascular diseases are highly prevalent.
背景：尽管已有报道，腹主动脉钙化在一般人群中成为其心血管疾病死亡率的预测因子，但对于血管钙化及心血管疾病患病率较高的持续血透的患者群中腹主动脉钙化是否同样是其心血管疾病死亡率的预测因子尚不确定。
还不清楚，其STUDY DESIGN: Cohort study.
研究设计：队列研究
SETTINGS & PARTICIPANTS: 515 patients on maintenance hemodialysis therapy at a single center.
环境与受试者：单中心515例行持续血液透析患者。
PREDICTOR: AAC evaluated in a plain roentgenograph of the lateral abdomen at baseline.
测量仪器：在基线，腹部X线侧位片评估腹主动脉钙化
OUTCOMES & MEASUREMENTS: All-cause and cardiovascular death.
结果测量：各种原因死亡和心血管死亡
RESULTS: Mean age was 60 +/- 12 (SD) years. AAC was present in 291 patients (56.5%). During a mean follow-up period of 51 +/- 17 months, there were 103 all-cause deaths, of which 41 were from cardiovascular diseases. Of patients with and without AAC, 27.8% and 9.8% died, respectively (11.6% and 3.1% of cardiovascular diseases, respectively). Kaplan-Meier analysis showed that all-cause mortality was significantly greater in patients with AAC compared to those without (P < 0.0001, log-rank test). Similarly, cardiovascular mortality was significantly greater in the former than in the latter group (P = 0.0001, log-rank test). Multivariate Cox proportional hazards analysis found that the presence of AAC was significantly associated with increased all-cause mortality (hazard ratio, 2.07; 95% confidence interval, 1.21 to 3.56; P < 0.01) and increased cardiovascular mortality (hazard ratio, 2.39; 95% confidence interval, 1.01 to 5.66; P < 0.05) after adjustment for age, hemodialysis duration, presence of diabetes, serum albumin level, and C-reactive protein level.
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作者:admin@医学,生命科学 2011-04-19 05:11
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