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【编译】T细胞调节：是＂福＂还是＂祸＂
Regulatory T cells: friend or foe in immunity to infection?
来源
Nature Reviews Immunology 4, 841-855 (2004); doi:10.1038/nri1485
http://www.nature.com/cgi-taf/DynaPage.taf?file=/nri/journal/v4/n11/abs/nri1485_fs.html&dynoptions=doi1114934414
摘要原文
Homeostasis in the immune system depends on a balance between the responses that control infection and tumour growth and the reciprocal responses that prevent inflammation and autoimmune diseases. It is now recognized that regulatory T cells have a crucial role in suppressing immune responses to self-antigens and in preventing autoimmune diseases. Evidence is also emerging that regulatory T cells control immune responses to bacteria, viruses, parasites and fungi. This article explores the possibility that regulatory T cells can be both beneficial to the host, through limiting the immunopathology associated with anti-pathogen immune responses, and beneficial to the pathogen, through subversion of the protective immune responses of the host.
编译
免疫系统的稳定依赖于控制感染和肿瘤生长以及预防炎症和自身性免疫疾病之间的反应的平衡。现在已经明确，T细胞在抑制对自身抗原的免疫反应和阻止自身性免疫疾病中起关键作用。有研究表明调节性T细胞可以控制对细菌、病毒、寄生虫和真菌的免疫反应。本文发现，调节性T细胞既可以通过限制因抗病原免疫引起的免疫病理来保护宿主，又可通过下调宿主的保护性免疫来保护病原。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-22 21:10
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