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【文摘发布】术中肝组织活检因发现有PSC组织学
Author:Hasegawa Y, Kawachi S, Shimazu M, Hoshino K, Tanabe M, Fuchimoto Y, Obara H, Shinoda M, Shimizu H, Yamada Y, Akatsu T, Irie R, Sakamoto M, Morikawa Y, Kitajima M.
source:Am J Transplant. 2007 Jul 5
IF:6.843(2006)
Liver transplantation is the only curative treatment known to date for end-stage liver disease occurring as a result of primary sclerosing cholangitis (PSC). Here, we report a case in which living donor liver transplantation (LDLT) for PSC was cancelled because of histological abnormalities in intraoperative biopsy of the donor liver. The donor was the mother of the recipient, and her preoperative evaluation revealed no abnormalities. In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct. These histological findings were identical to those of early-stage PSC; therefore, the LDLT was called off. The experience in this case suggests that preoperative liver biopsy may be useful to exclude first-degree relative donors with potential PSC prior to LDLT for PSC. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title Discontinuation of Living Donor Liver Transplantation for PSC Due to Histological Abnormalities in Intraoperative Donor Liver Biopsy.
题目：因术中供体肝组织活检发现有组织学异常而终止活体供肝移植治疗原发性硬化性胆管炎
Author:Hasegawa Y, Kawachi S, Shimazu M, Hoshino K, Tanabe M, Fuchimoto Y, Obara H, Shinoda M, Shimizu H, Yamada Y, Akatsu T, Irie R, Sakamoto M, Morikawa Y, Kitajima M.
作者：Hasegawa Y, Kawachi S, Shimazu M, Hoshino K, Tanabe M, Fuchimoto Y, Obara H, Shinoda M, Shimizu H, Yamada Y, Akatsu T, Irie R, Sakamoto M, Morikawa Y, Kitajima M.
source:Am J Transplant. 2007 Jul 5
出处：《美国移植杂志》2007年7月5日
IF:6.843(2006)
2006年该杂志影响因子：6.843
Liver transplantation is the only curative treatment known to date for end-stage liver disease occurring as a result of primary sclerosing cholangitis (PSC).
肝移植是迄今为止已知的治疗因原发性硬化性胆管炎(PSC)导致的终末期肝病的唯一的治愈疗法。
Here, we report a case in which living donor liver transplantation (LDLT) for PSC was cancelled because of histological abnormalities in intraoperative biopsy of the donor liver.
在此，我们报道一例因术中供体肝组织活检发现组织学异常而取消活体供肝移植(LDLT)治疗PSC的病例。
The donor was the mother of the recipient, and her preoperative evaluation revealed no abnormalities. In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct.
供体是受体的母亲，而她的术前评估显示无异常。在供体手术中，供体肝组织活检显示：门脉区域扩张伴淋巴细胞浸润以及胆管周围致密向心性纤维化。
These histological findings were identical to those of early-stage PSC; therefore, the LDLT was called off. The experience in this case suggests that preoperative liver biopsy may be useful to exclude first-degree relative donors with potential PSC prior to LDLT for PSC.
这些组织学检查所见与早期PSC的那些组织学表现是完全一致的；因此，取消了LDLT。这个病例的经验提示：在采用LDLT 治疗 PSC之前，手术前的肝组织活检或许有助于排除合并潜在性PSC的一级亲属供体。
编译：
【据《美国移植杂志》2007年7月5日报道】因术中供体肝组织活检发现有组织学异常而终止活体供肝移植治疗原发性硬化性胆管炎（作者Hasegawa Y, Kawachi S, Shimazu M等）
2006年该杂志影响因子：6.843
肝脏移植是迄今为止已知的治疗因原发性硬化性胆管炎(PSC)导致的终末期肝病的唯一的治愈疗法。
在此，我们报道一例因术中供体肝组织活检发现组织学异常而取消活体供肝移植(LDLT)治疗PSC的病例。供体是受体的母亲，而她的术前评估显示无异常。在供体手术中，供体肝组织活检显示：门脉区域扩张伴淋巴细胞浸润以及胆管周围致密向心性纤维化。这些组织学检查所见与早期PSC的那些组织学表现是完全一致的；因此，取消了活体供肝移植。
这个病例的经验提示：在采用活体供肝移植治疗原发性硬化性胆管炎之前，手术前的肝组织活检或许有助于排除合并潜在性PSC的一级亲属供体。
翻译不妥之处，还请各位战友指正，谢！ [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-04-20 05:11
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