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【文摘发布】骨组织wnt信号转导的体内分析
Title：In Vivo Analysis of Wnt Signaling in Bone
Author：Donald A. Glass, II and Gerard Karsenty
Resource: Endocrinology 2007 148: 2630-2634
Abstract：
Bone remodeling requires osteoblasts and osteoclasts working in concert to maintain a constant bone mass. The dysregulation of signaling pathways that affect osteoblast or osteoclast differentiation or function leads to either osteopenia or high bone mass. The discovery that activating and inactivating mutations in low-density lipoprotein receptor-related protein 5, a putative Wnt coreceptor, led to high bone mass and low bone mass in human beings, respectively, generated a tremendous amount of interest in the possible role of the Wnt signaling pathway in the regulation of bone remodeling. A number of mouse models have been generated to study a collection of Wnt signaling molecules that have been identified as regulators of bone mass. These mouse models help establish the canonical Wnt signaling pathway as a major regulator of chondrogenesis, osteoblastogenesis, and osteoclastogenesis. This review will summarize these advances.
PMID: 17395705 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title：In Vivo Analysis of Wnt Signaling in Bone
题目：骨组织wnt信号转导的体内分析
Author：Donald A. Glass, II and Gerard Karsenty
作者：Glass DA II, Karsenty G
Resource: Endocrinology 2007 148: 2630-2634
来源：内分泌学.2007 148: 2630-2634
Abstract：
Bone remodeling requires osteoblasts and osteoclasts working in concert to maintain a constant bone mass. The dysregulation of signaling pathways that affect osteoblast or osteoclast differentiation or function leads to either osteopenia or high bone mass.
摘要：
骨重塑过程需要成骨细胞和破骨细胞间的相互协调，从而维持骨基质的连续性。影响成骨细胞或破骨细胞分化或功能的信号通路调节异常可导致骨质减少症或骨量升高。
The discovery that activating and inactivating mutations in low-density lipoprotein receptor-related protein 5, a putative Wnt coreceptor, led to high bone mass and low bone mass in human beings, respectively, generated a tremendous amount of interest in the possible role of the Wnt signaling pathway in the regulation of bone remodeling.
有研究发现，低密度脂蛋白受体相关蛋白5(一种可能的Wnt辅助受体)的激活和失活在人类可分别导致高骨量和低骨量，这引起了Wnt信号途径在骨重塑调节中所起作用的极大兴趣。
A number of mouse models have been generated to study a collection of Wnt signaling molecules that have been identified as regulators of bone mass. These mouse models help establish the canonical Wnt signaling pathway as a major regulator of chondrogenesis, osteoblastogenesis, and osteoclastogenesis. This review will summarize these advances.
人们利用许多小鼠模型来研究骨重塑中可作为调节因子的各种Wnt信号分子。这些小鼠模型有助于在软骨形成、成骨细胞形成和破骨细胞形成中建立标准的Wnt信号途径，该途径可作为上述过程中一种主要的调节因子。本综述将对这方面的进展进行总结。
编译后：共306字
Donald A. Glass, II等综述了骨组织wnt信号转导的体内分析的相关进展，文章发表在2007年第148期《内分泌学》。骨重塑过程需要成骨细胞和破骨细胞间的相互协调，从而维持骨基质的连续性。影响成骨细胞或破骨细胞分化或功能的信号通路调节异常可导致骨质减少症或骨量升高。有研究发现，低密度脂蛋白受体相关蛋白5(一种可能的Wnt辅助受体)的激活和失活在人类可分别导致高骨量和低骨量，这引起了Wnt信号途径在骨重塑调节中所起作用的极大兴趣。人们利用许多小鼠模型来研究骨重塑中可作为调节因子的各种Wnt信号分子。这些小鼠模型有助于在软骨形成、成骨细胞形成和破骨细胞形成中建立标准的Wnt信号途径，该途径可作为上述过程中一种主要的调节因子。本综述将对这方面的进展进行总结。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-18 05:11
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