Author: Lai WK, Curbishley SM, Goddard S, Alabrabra E, Shaw J, Youster J, McKeating J, Adams DH.
Resourse: J Hepatol. 2007 Apr 12; [Epub ahead of print]
BACKGROUND/AIMS: In most cases infection with hepatitis C results in chronic infection as a consequence of viral subversion and failed anti-viral immune responses. The suggestion that dendritic cells are defective in chronic HCV infection led us to investigate the phenotype and function of liver-derived myeloid (mDC) and plasmacytoid (pDC) dendritic cells in patients with chronic HCV infection. METHODS: Liver DCs were isolated without expansion in cytokines from human liver allowing us to study unmanipulated tissue-resident DCs ex vivo. RESULTS: Compared with mDCs isolated from non-infected inflamed liver mDCs from HCV-infected liver demonstrated higher expression of MHC class II, CD86 and CD123, were more efficient stimulators of allogeneic T-cells and secreted less IL-10. Reduced IL-10 secretion may be a factor in the enhanced functional properties of mDCs from HCV infected liver because antibody depletion of IL-10 enhanced the ability of mDCs from non-infected liver to stimulate T-cells. In contrast, pDCs were present at lower frequencies in HCV-infected liver and expressed higher levels of the regulatory receptor BDCA-2. CONCLUSIONS: In HCV-infected liver the combination of enhanced mDC function and a reduced number of pDCs may contribute to viral persistence in the face of persistent inflammation.
PMID: 17467113 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Hepatitis C is associated with perturbation of intrahepatic myeloid and plasmacytoid dendritic cell function
作者:admin@医学,生命科学 2011-03-09 13:24