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【Medicalnewstoday--编译】前列腺癌最新研究聚焦

前列腺癌最新研究聚焦激素与蛋白质 Medicalnewstoday: 2005-04-29

近日,加拿大麦克马司特大学(McMaster University)健康科学系的两名研究者获得了加拿大前列腺癌研究基金会的奖助金。

前列腺癌是仅次于由吸烟引起的肺癌的第二大男性癌症杀手。加拿大前列腺癌症研究基金会估计每八个加拿大男性中就有一个会患上这种疾病,而其中的四分之一会因此而丧失生命。

医学助理教授Damu Tang获得了12万美元用于研究新近确认的蛋白质PTEN,以弄清它在阻止前列腺癌发病进程中的重要作用。

在前列腺癌的早期,肿瘤的生长需要雄激素,直到发展到一定程度雄性激素不再被需要。临床观察证明有50%的晚期前列腺肿瘤中没有PTEN。研究者认为,PTEN的缺损令机体失去了一道关键防线,使前列腺癌的演进不再依赖雄激素。

生物化学和生物医学助理教授Sujata Persad获得了6万美元用于研究β-连环蛋白,它与前列腺癌的初起、发展和转移有较大的关联。β-连环蛋白在细胞中有两种重要作用:使细胞粘合在一起并促进细胞的生长和生存。

β-连环蛋白可以在结构上接上糖分子而被修饰。Persad的研究小组将研究β-连环蛋白被修饰后在促进细胞的生长和存活上的作用是否会受到影响。

在前列腺肿瘤细胞中该蛋白被修饰的比率小于正常细胞,用糖分子修饰的方法调整β-连环蛋白的功能可能会阻止前列腺肿瘤细胞的形成。

麦克马司特大学座落于加拿大哈密尔顿市,拥有世界一流的师资、知识水平和研究设备,在校生超过2万3千人,并有11万2千多名女校友分布于128个国家。

原文:
http://www.medicalnewstoday.com/medicalnews.php?newsid=23563

New prostate cancer studies look at hormone and protein connection
29 Apr 2005

Two researchers at McMaster University's Faculty of Health Sciences have been awarded research grants from the Prostate Cancer Research Foundation of Canada.

Prostate cancer is the second most deadly form of cancer in men after smoke related lung cancer. It is estimated by the Prostate Foundation of Canada that one in eight Canadian men will develop the disease, and one in four of them will die from prostate cancer.

Damu Tang, assistant professor, Medicine, has received $120,000 to research the newly identified protein PTEN, to see how important it is in preventing prostate cancer progression.

In its early stage, prostate cancer requires the hormone androgen to grow, until it progresses to a point where androgen is no longer needed. Clinical observations demonstrate clearly that 50 percent of advanced prostate cancers have no PTEN.

It is believed that the loss of PTEN removes a crucial protection, which facilitates prostate cancer progression into the androgen-independent stage.

Sujata Persad, assistant professor, Biochemistry and Biomedical Sciences was awarded $60,000 to study Beta-catenin, a protein highly associated with prostate cancer initiation, progression and metastases. Beta-catenin plays two important roles inside cells: it functions to glue cells to each other and it promotes cell growth and survival.

Beta--catenin can be modified by having sugar molecules attached to its structure. Persad's team will investigate whether modifying beta-catenin affects its role in promoting cell growth and survival. Modification happens less frequently in prostate cancer cells than in normal prostate cells, and using sugar modification may regulate the function of beta-catenin to prevent tumor formation in prostate cells.

McMaster University, named Canada's Research University of the Year by Research InfoSource, has world-renowned faculty and state-of-the-art research facilities. McMaster's culture of innovation fosters a commitment to discovery and learning in teaching, research and scholarship. Based in Hamilton, the University has a student population of more than 23,000 and more than 112,000 alumni in 128 countries. [标签:content1][标签:content2]

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作者:admin@医学,生命科学    2011-03-05 17:22
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