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【medical-news】一些血液生化标志物能够预测老年
The finding comes from a study of 1,125 people who were in their late 70s when their blood was first tested. Four and a half years later, 104 of them had Alzheimer's disease.
Those with the highest blood levels of A-beta 42, a major component of the plaque that clogs the brains of Alzheimer's patients, were far more likely to get Alzheimer's than were those with the lowest A-beta 42 levels.
"Compared with individuals with low [blood] A-beta 42 levels at baseline, those with high A-beta 42 levels had more than a threefold increased risk of developing Alzheimer's disease over an average of 4.5 years," conclude Columbia University researcher Nicole Schupf, PhD, DrPH, and colleagues.
Interestingly, just before study participants developed the first signs of Alzheimer's disease, their A-beta 42 blood levels suddenly dropped. This, the researchers suggest, is a sensitive sign that a person has recently developed Alzheimer's.
Different studies of plaque peptides in the blood have come up with different results. Timing may have everything to do with this, Schupf and colleagues suggest.
When tested well before symptoms appear, the study suggests, people on the road to Alzheimer's will have high levels of A-beta in their blood. But when they finally get Alzheimer's, A-beta 42 sticks in the brain -- and blood levels drop.
The study also shows that blood levels of a second plaque peptide, A-beta 40, are not higher in people who eventually develop Alzheimer's disease.
The researchers say more work is needed to detail the patterns of change in A-beta levels and to see whether these patterns differ in people with genetic and environmental risk factors for Alzheimer's.
Schupf and colleagues report their findings in the Sept. 16 issue of Proceedings of the National Academy of Sciences. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Sept. 8, 2008 -- High blood levels of a plaque peptide may predict Alzheimer's disease in elderly people.
2008年9月8日——血液中高水平的菌斑肽可能可以预测老年人的阿尔茨海默病。
The finding comes from a study of 1,125 people who were in their late 70s when their blood was first tested. Four and a half years later, 104 of them had Alzheimer's disease.
结果来自对1125名75岁到79岁的老人的研究。他们血液中第一次检测出该物质，四年半后，其中104名患了阿尔茨海默病。
Those with the highest blood levels of A-beta 42, a major component of the plaque that clogs the brains of Alzheimer's patients, were far more likely to get Alzheimer's than were those with the lowest A-beta 42 levels.
那些有着最高的血A-beta 42水平的人比低A-beta 42的人更易患阿尔茨海默病。A-beta 42是阻塞阿尔茨海默病患者大脑斑块的主要组成成分。
"Compared with individuals with low [blood] A-beta 42 levels at baseline, those with high A-beta 42 levels had more than a threefold increased risk of developing Alzheimer's disease over an average of 4.5 years," conclude Columbia University researcher Nicole Schupf, PhD, DrPH, and colleagues.
“与那些血A-beta 42处于基线水平的个体相比，高A-beta 42水平的个体平均在4.5年间，发展成AD的危险高三倍多。”哥伦比亚大学研究员Nicole Schupf博士和他的同事总结说。
Interestingly, just before study participants developed the first signs of Alzheimer's disease, their A-beta 42 blood levels suddenly dropped. This, the researchers suggest, is a sensitive sign that a person has recently developed Alzheimer's.
有趣的是，在正要研究参与者发展出第一个AD的症状时，他们血里的A-beta 42水平突然下降。研究者认为，这个一个最近会发展成AD的敏感指标。
Different studies of plaque peptides in the blood have come up with different results. Timing may have everything to do with this, Schupf and colleagues suggest.
对血液中菌斑肽的不同研究得出不同的结论。研究的时间与这个结论密切相关。Schupf和他的同事说。
When tested well before symptoms appear, the study suggests, people on the road to Alzheimer's will have high levels of A-beta in their blood. But when they finally get Alzheimer's, A-beta 42 sticks in the brain -- and blood levels drop.
当对症状即将出现的病人的研究提示，在发展成AD的过程中他们血中的A-beta水平将会升高。但是当他们得了AD后，A-beta留在大脑，血中的水平下降了。
The study also shows that blood levels of a second plaque peptide, A-beta 40, are not higher in people who eventually develop Alzheimer's disease.
这个研究同样表明最终发展成AD的患者血液中第二种菌斑肽A-beta 40的水平并不比其它人高。
The researchers say more work is needed to detail the patterns of change in A-beta levels and to see whether these patterns differ in people with genetic and environmental risk factors for Alzheimer's.
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作者:admin@医学,生命科学 2011-03-01 17:11
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