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【medical-news】肺癌普查工作中，过度诊断现象十
2/7/2007
By: Reuters Health
http://www.auntminnie.com/index.asp?Sec=sup&Sub=cto&Pag=dis&ItemId=74535
NEW YORK (Reuters Health), Feb 7 - Overdiagnosis is common in computed tomography (CT) lung cancer screening, according to a report in the February issue of Radiology.
"Screening high-risk patients with chest CT may result in lung cancer overdiagnosis, especially in women," Dr. Rebecca M. Lindell from the Mayo Clinic, Rochester, MN, told Reuters Health.
Dr. Lindell and associates evaluated the size, morphology, location, morphologic change, and growth rate of new and existing lung cancers detected in high-risk individuals who underwent annual screening chest CT for five years.
Sixty-one tumors were diagnosed in 1,520 participants in the lung cancer screening study, the authors report. Thirty-one were incidence tumors and 30 were prevalence tumors.
The new cancers detected by CT were most commonly nonbronchoalveolar adenocarcinomas, the investigators say.
Mean volume doubling time in the 48 tumors that could be assessed was 518 days, the results indicate. The 13 tumors with a volume doubling time longer than 400 days were stage IA (10 tumors), IB (1 tumor), or II (2 tumors).
Eleven of the 13 overdiagnosed tumors (that is, those with a volume doubling time in excess of 400 days) occurred in women, the report indicates.
Tumors were more commonly detected in the right lung than in the left lung, the researchers note, and most tumors were in the upper lobes.
"Overdiagnosis, especially in women, may be a substantial concern in lung cancer screening," the authors conclude.
"The effectiveness of lung cancer screening hasn't been proven; therefore, one can not assess the cost-effectiveness yet," Dr. Lindell added.
Last Updated: 2007-02-06 15:55:29 -0400 (Reuters Health)
Radiology 2007;242:555-562. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 感谢蓝色幻想对该篇翻译难点上给予的帮助 谢谢没头脑战友指正! 个人观点，仅供参考：
Screening high-risk patients with chest CT may result in lung cancer overdiagnosis, especially in women
对高危病人进行胸部CT筛查可能会导致肺癌过度诊断现象的发生，特别是多见于女性病人
应用胸部CT筛查高危患者（尤其是女性患者）可能会引起肺癌的过度诊断。 厉害 佩服
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作者:admin@医学,生命科学 2011-03-01 05:14
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