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【文摘发布】HBeAg阴性、血清谷丙转氨酶持续正常
Authors:Lin CL, Liao LY, Liu CJ, Yu MW, Chen PJ, Lai MY, Chen DS, Kao JH
Resource: Hepatology. 2007 May;45(5):1193-8
Abstract:
Chronic hepatitis B patients with high-normal serum ALT (levels of 0.5-1x upper limit of normal) are still at risk of liver disease progression. We thus investigated the correlation between serum ALT level and hepatitis B viral factors in HBeAg-negative carriers with persistently normal serum ALT level (PNALT). Baseline clinical and virological features of 414 HBeAg-negative carriers, including 176 (42.5%) with low-normal ALT (levels of less than 0.5x upper limit of normal) and 238 (57.5%) with high-normal ALT, were compared. Compared with HBV carriers with low-normal ALT, those with high-normal ALT were older (41 vs. 37 years, P < 0.001) and had a greater frequency of serum HBV DNA level >104 copies/ml (63.4% vs. 47.5%, P < 0.001) as well as a higher prevalence of basal core promoter T1762/A1764 mutant (36.5% vs. 24.2%, P = 0.01). Multivariate analysis showed that factors associated with a high-normal serum ALT level included male sex [odds ratio (OR), 1.82; 95% confidence interval (CI), 1.10-3.01, P = 0.019], increasing age (OR, <30 years: 1, reference; 30-39 years: 2.43, 95% CI, 1.18-5.03, P = 0.016; 40-49 years: 4.22, 95% CI, 1.99-8.93, P < 0.001; >/=50 years: 4.06, 95% CI, 1.69-9.78, P = 0.002) and serum HBV DNA level >104 copies/ml (OR, 1.83; 95% CI, 1.07-3.13, P = 0.027). Conclusion: HBeAg-negative patients with persistently normal ALT are not a homogenous group, and those with high-normal ALT share some of the characteristics that have been associated with adverse long-term outcomes. (HEPATOLOGY 2007;45:1193-1198.).
PMID: 17464993 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title:Hepatitis B viral factors in HBeAg-Negative carriers with persistently normal serum alanine aminotransferase levels.
HBeAg阴性、血清谷丙转氨酶持续正常的的HBV携带者的相关因素分析 Conclusion: HBeAg-negative patients with persistently normal ALT are not a homogenous group, and those with high-normal ALT share some of the characteristics that have been associated with adverse long-term outcomes. (HEPATOLOGY 2007;45:1193-1198.).
结论：血清谷丙转氨酶持续正常的HBeAg阴性的患者非同系的人群，那些有high-normal ALT的患者共享了一些和不良的长期结果相关的一些特征 对该题目的翻译有异议：
Hepatitis B viral factors in HBeAg-Negative carriers with persistently normal serum alanine aminotransferase levels.
HBeAg阴性、血清谷丙转氨酶持续正常的的HBV携带者的相关因素分析
本人认为应该改为：HBeAg阴性、血清谷丙转氨酶持续正常的的HBV携带者的病毒学因素分析
beebeeliang wrote:
对该题目的翻译有异议：
Hepatitis B viral factors in HBeAg-Negative carriers with persistently normal serum alanine aminotransferase levels.
HBeAg阴性、血清谷丙转氨酶持续正常的的HBV携带者的相关因素分析
本人认为应该改为：HBeAg阴性、血清谷丙转氨酶持续正常的的HBV携带者的病毒学因素分析
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作者:admin@医学,生命科学 2011-03-01 05:12
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