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【文摘发布】肺部给药的粉体工程
Author：Albert H. L. Chow1 , Henry H. Y. Tong2, Pratibhash Chattopadhyay3 and Boris Y. Shekunov3
Resource:Pharmaceutical Research, 2007 March 24(3) ：411-437
Abstract：With the rapidly growing popularity and sophistication of inhalation therapy, there is an increasing demand for tailor-made inhalable drug particles capable of affording the most efficient delivery to the lungs and the most optimal therapeutic outcomes. To cope with this formulation demand, a wide variety of novel particle technologies have emerged over the past decade. The present review is intended to provide a critical account of the current goals and technologies of particle engineering for the development of pulmonary drug delivery systems. These technologies cover traditional micronization and powder blending, controlled solvent crystallization, spray drying, spray freeze drying, particle formation from liquid dispersion systems, supercritical fluid processing and particle coating. The merits and limitations of these technologies are discussed with reference to their applications to specific drug and/or excipient materials. The regulatory requirements applicable to particulate inhalation products are also reviewed briefly.
PMID: 17245651 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title： Particle Engineering for Pulmonary Drug Delivery
题目：肺部给药的粉体工程
Author：Albert H. L. Chow1 , Henry H. Y. Tong2, Pratibhash Chattopadhyay3 and Boris Y. Shekunov3
Resourceharmaceutical Research, 2007 March 24(3) ：411-437
摘要：随着吸入治疗技术的迅速发展和成熟，对合适的吸入药物粉体的需求日益增加，该药物粉体能够最高效的到达肺部从而达到最佳治疗效果的。为了满足这一需要，在过去的十年中各种各样的新的粉体技术层出不穷。这篇文章旨在综述与肺部给药系统发展相关的粉体工程的一些现代进展和技术。这些技术包括传统的微粉化技术和混合粉末，可控溶解结晶化，干粉喷雾，冷冻干粉喷雾，液相弥散系统的粉体形成，流体超临界过程和微粒包衣。文章对这些技术应用于药物和/或者赋形剂材料的利弊进行了讨论。同时对应用与颗粒吸入产品的调节性要求进行了简要综述。
PMID: 17245651 第一次发文摘，呵呵，是不是摘要太短了 呵呵，大家都是刚开始。
难得的是能一直坚持下去。 有几处还请斟酌一下
1.The present review is intended to provide a critical account of the current goals and technologies of particle engineering for the development of pulmonary drug delivery systems.
2. powder blending,
3.controlled solvent crystallization
4. spray drying
5.spray freeze drying
6.particle formation from liquid dispersion systems 不该法在这里，呵呵，纪念一下
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作者:admin@医学,生命科学 2011-02-18 05:12
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