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【drug-news】美沙酮有望医治难治性白血病
NEW YORK (Reuters Health) - Methadone, a drug used to treat people addicted to heroin and other opioid drugs, holds promise as a new treatment for leukemia, especially treatment-resistant leukemia, according to results of a study.
Laboratory tests show that methadone kills leukemia cells without harming healthy blood cells, researchers at the University of Ulm in Germany report in a paper published today in the journal Cancer Research. Methadone was even effective in killing leukemia cells resistant to killing by chemotherapy and radiation.
"Leukemia cells express opioid receptors, to which methadone binds," study chief Dr. Claudia Friesen told Reuters Health. "Surprisingly, we found that methadone kills leukemia cells efficiently. We never expected that."
These results "provide the foundation for new strategies using methadone as an additional anticancer drug in leukemia therapy, especially when conventional therapies are less effective," the investigators conclude.
"We find this very exciting, because once conventional treatments fail, which occurs in old and also in young patients, they have no other options," Friesen said.
She predicts that methadone will have similar effects in other cancers that express opioid receptors. "In our lab we found that we also can kill solid tumors," she added.
Friesen and her team are studying methadone alone and in combination with other chemotherapy drugs in animal models of cancer.
SOURCE: Cancer Research, August 1, 2008.
http://www.reuters.com/article/healthNews/idUSCOL15998820080801 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 NEW YORK (Reuters Health) - Methadone, a drug used to treat people addicted to heroin and other opioid drugs, holds promise as a new treatment for leukemia, especially treatment-resistant leukemia, according to results of a study.
路透社纽约报道：美沙酮是一种原本用于治疗海洛因和其他阿片类药物成瘾患者的药物，研究表明它可能成为白血病的一种新的治疗药物，特别是用于治疗难治性白血病。
Laboratory tests show that methadone kills leukemia cells without harming healthy blood cells, researchers at the University of Ulm in Germany report in a paper published today in the journal Cancer Research. Methadone was even effective in killing leukemia cells resistant to killing by chemotherapy and radiation.
在今天出版的肿瘤研究杂志刊登的一篇论文中德国乌尔姆大学的研究人员报道实验显示美沙酮可杀死白血病细胞而不损伤健康血细胞。美沙酮甚至对放、化疗抵抗的白血病细胞也有杀伤作用。
"Leukemia cells express opioid receptors, to which methadone binds," study chief Dr. Claudia Friesen told Reuters Health. "Surprisingly, we found that methadone kills leukemia cells efficiently. We never expected that."
研究负责人Claudia Friesen博士接受路透社采访时说：“白血病细胞表达阿片受体，美沙酮能与之结合。令人惊讶的是，我们发现美沙酮可有效地杀伤白血病细胞。这出乎我们的意料。”
These results "provide the foundation for new strategies using methadone as an additional anticancer drug in leukemia therapy, especially when conventional therapies are less effective," the investigators conclude.
研究者总结道：“这些结果为将美沙酮作为一种抗肿瘤药物用于白血病治疗新方案奠定了基础，特别是对于传统化疗效果不明显的白血病。”
"We find this very exciting, because once conventional treatments fail, which occurs in old and also in young patients, they have no other options," Friesen said.
Friesen说：“这令人非常激动，因为在年长或年幼的患者，一旦传统治疗无效，他们就没有其他选择了。”
She predicts that methadone will have similar effects in other cancers that express opioid receptors. "In our lab we found that we also can kill solid tumors," she added.
她预言美沙酮在表达阿片受体的其他肿瘤也会有类似的作用。另外她说：“在我们的实验室我们发现美沙酮也可杀伤实体瘤。”
Friesen and her team are studying methadone alone and in combination with other chemotherapy drugs in animal models of cancer.
Friesen和她的研究人员正在研究美沙酮单独或与其他化疗药物合用对肿瘤动物模型的作用。
编译如下：
路透社纽约报道：美沙酮是一种原本用于治疗海洛因和其他阿片类药物成瘾患者的药物，研究表明它可能成为白血病的一种新的治疗药物，特别是用于治疗难治性白血病。
在今天出版的肿瘤研究杂志刊登的一篇论文中德国乌尔姆大学的研究人员报道实验显示美沙酮可杀死白血病细胞而不损伤健康血细胞。美沙酮甚至对放、化疗抵抗的白血病细胞也有杀伤作用。
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作者:admin@医学,生命科学 2011-06-28 18:00
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