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【文摘发布】高尿酸血症者其代谢综合征患病率
Author:Hyon K. Choi MD, DrPH, Earl S. Ford MD, MPH
Resource:The American Journal of Medicine ,Volume 120, Issue 5, May 2007, Pages 442-447
ABSTRACT
Purpose
The link between hyperuricemia and insulin resistance has been noted, but the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear. Our objective was to determine the prevalence of the metabolic syndrome according to serum uric acid levels in a nationally representative sample of US adults.
Methods
By using data from 8669 participants aged 20 years and more in The Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of the metabolic syndrome at different serum uric acid levels. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP) III criteria to define the metabolic syndrome.
Results
The prevalences of the metabolic syndrome according to the revised NCEP/ATP III criteria were 18.9% (95% confidence interval [CI], 16.8-21.0) for uric acid levels less than 6 mg/dL, 36.0% (95% CI, 32.5-39.6) for uric acid levels from 6 to 6.9 mg/dL, 40.8% (95% CI, 35.3-46.4) for uric acid levels from 7 to 7.9 mg/dL, 59.7% (95% CI, 53.0-66.4) for uric acid levels from 8 to 8.9 mg/dL, 62.0% (95% CI, 53.0-66.4) for uric acid levels from 9 to 9.9 mg/dL, and 70.7% for uric acid levels of 10 mg/dL or greater. The increasing trends persisted in subgroups stratified by sex, age group, alcohol intake, body mass index, hypertension, and diabetes. For example, among individuals with normal body mass index (<25 kg/m2), the prevalence increased from 5.9% (95% CI, 4.8-7.0), for a uric acid level of less than 6 mg/dL, to 59.0%, (95% CI, 20.1-97.9) for a uric acid level of 10 mg/dL or greater. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower.
Conclusions
These findings from a nationally representative sample of US adults indicate that the prevalence of the metabolic syndrome increases substantially with increasing levels of serum uric acid. Physicians should recognize the metabolic syndrome as a frequent comorbidity of hyperuricemia and treat it to prevent serious complications. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title: Prevalence of the Metabolic Syndrome in Individuals with Hyperuricemia
题目：高尿酸血症患者代谢综合征患病率 编译：中文字数（531）
加拿大英属哥伦比亚大学温哥华总医院Hyon K. Choi等人发表在2007年5月出版的《美国医药杂志》上的一项研究结果表明随着血尿酸水平增高，代谢综合征发病率相应增高。内科医生应识别高尿酸血症常见的同病－代谢综合征并加以治疗，以预防此病引起的各种并发症。（The American Journal of Medicine ,Volume 120, Issue 5, May 2007, Pages 442-447）
高尿酸血症和胰岛素抵抗有明确联系。在高尿酸血症患者中，以新的参考标准诊断代谢综合征，其发病率还不清楚。基于此，利用第三次全国健康与营养调查(1988-1994，美国)数据，根据不同的血尿酸水平，研究分析代谢综合征的发病率。8669名受试者，年龄≥20岁。利用全美胆固醇计划成人治疗小组(NCEP/ATP)推荐的III 标准（修订版）和初版标准诊断代谢综合征。
结果如下：根据NCEP/ATP III 标准（修订版），当血尿酸<6mg/dL时，代谢综合征发病率为18.9% (95%可信区间16.8-21.0)；血尿酸6-6.9mg/dL时，发病率为36.0% (95%可信区间32.5-39.6)；血尿酸7-7.9 mg/dL时，发病率为40.8%(95%可信区间35.3-46.4)；血尿酸8-8.9mg/dL时，发病率为59.7% (95%可信区间53.0-66.4)；血尿酸9-9.9 mg/dL时，发病率为62.0% (95%可信区间53.0-66.4)；血尿酸≥10 mg/dL时，发病率为70.7%。根据性别、年龄、饮酒、体重指数、高血压和糖尿病分层的各亚组分析也显示上述趋势。例如，在正常体重指数组(<25 kg/m2)，当血尿酸水平从<6mg/dL升至≥10 mg/dL时，代谢综合征发病率从5.9% (95%可信区间4.8-7.0)增高至59.0%, (95%可信区间20.1-97.9)。根据NCEP/ATP 初版标准进行分析，相应的发病率轻度减小。 提几点小问题:
1.题目中“代谢综合症”应为“代谢综合征”；
2.目的中“我们根据”改为“本研究根据”；
3.方法中“利用第三次全国健康与营养调查(1988-1994,美国)数据，8669名参与者，年龄≥20岁。”改为“本研究利用第三次全国健康与营养调查(1988-1994,美国)的数据纳入年龄≥20岁的8669例受试者”。 谢谢dmfylovewmh战友前来指导！已修改。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-05-08 05:11
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