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【bio-news】干细胞协助中风小鼠模型恢复
WASHINGTON (Reuters) - Transplanting brain cells produced from human embryonic stem cells helped fix stroke damage in the brains of rats, according to scientists who hope to test the same thing in people within about five years.
Researchers have been looking for ways to repair the brain damage from a stroke, which can cause permanent disability. In a study published on Tuesday, researchers at Stanford University School of Medicine in California reported that treatment involving human embryonic stem cells may be a solution.
Embryonic stem cells are the master cells that give rise to every cell and tissue in the body.
The Stanford team reported they restored lost limb function in rats that had stroke-related brain damage. They induced human embryonic stem cells to develop into neural stem cells that, once transplanted in the rats, developed into neurons and two other important types of brain cells.
The researchers hope to use this approach within about five years in studies involving people who have had strokes.
"We have a lot of evidence that we'll be able to use this kind of stem cell regenerative therapy in patients, including stroke patients," Stanford's Dr. Gary Steinberg, who helped lead the study, said in a telephone interview.
Writing in the Public Library of Science journal PLoS ONE, Steinberg's team described how they caused strokes in 10 rats and then transplanted neural stem cells into their brains.
The cells made their way to the damaged brain region and incorporated themselves into surrounding brain tissue.
The cells never grew uncontrollably into tumors in lab dishes or inside the rats, the scientists said. The transplanted cells helped repair the stroke damage and enabled the rats to recover lost function in front legs weakened as a result of the stroke, they added.
"It was not quite back to normal but, at least in the rat, it looks like it's going to be close to normal -- very impressive," Steinberg said.
"Now remember, this is a rat, not a human. We still have to make that step. But if we could achieve that kind of recovery in humans, we would have a great therapy," Steinberg added.
In a stroke, the blood supply to any part of the brain is blocked. This can occur when a blood vessel bringing blood to the brain is blocked by a blood clot, or when a blood vessel bursts, causing blood to leak into the brain.
If blood flow is halted for more than a few seconds, the brain is deprived of blood and oxygen, brain cells die and permanent damage can result.
Some people oppose the use of human embryonic stem cells on ethical grounds because creating the reservoirs of these cells for use in research involves the destruction of human embryos.
http://www.reuters.com/article/healthNews/idUSN1960584920080220
screen.width-333)this.width=screen.width-333" width=125 height=110 title="Click to view full 小鼠快跑.gif (125 X 110)" border=0 align=absmiddle> 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 粗译如下:
Stem cells help rats recover function after stroke
干细胞帮助中风小鼠模型功能恢复
WASHINGTON (Reuters) - Transplanting brain cells produced from humans embryonic stem cells helped fix stroke damage in the brains of rats, according to scientists who hope to test the same thing in people within about five years.
华盛顿(路透社)消息:科学家们说,移植人类胚胎干细胞所生之脑细胞,帮助中风小鼠修复脑内损害.科学家们希望5年内能将此研究实践于人类.
Researchers have been looking for ways to repair the brain damage from a stroke, which can cause permanent disability. In a study published on Tuesday, researchers at Stanford University School of Medicine in California reported that treatment involving human embryonic stem cells may be a solution.
研究人员们一直在寻找修复中风相关脑损害的方法,因为这种损害会导致永久性残疾.周2的一项研究中,加利福尼亚.斯坦福医科大学的研究人员们报道说,用人类胚胎干细胞治疗或许是个解决方法.
Embryonic stem cells are the master cells that give rise to every cell and tissue in the body.
胚胎干细胞是体内产生各种细胞与组织的主要细胞.
The Stanford team reported they restored lost limb function in rats that had stroke-related brain damage. They induced human embryonic stem cells to develop into neural stem cells that, once transplanted in the rats, developed into neurons and two other important types of brain cells.
斯坦福研究小组报道说,他们恢复了中风相关脑损伤小鼠所丧失的肢体功能.他们诱导人类胚胎干细胞发育成神经干细胞,而后者一旦被移植于小鼠,则会发育成神经元及其他两种重要的脑细胞.
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作者:admin@医学,生命科学 2011-05-01 05:14
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