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【medical-news】对于成年癌症患者，较长时间的蒽
Longer anthracycline therapy reduces heart failure in adult cancer patients
Stretching out a dose of chemotherapy over six or more hours may reduce the risk of heart problems caused by certain commonly used cancer drugs, according to a new review of recent research.
Anthracycline drugs like daunorubicin and doxorubicin are used to treat many types of solid tumors and blood cancers such as leukemias in adults and children.
Anthracycline therapy can be very successful at controlling cancer, but heart damage caused by anthracycline treatment 搃s a considerable and serious problem,?said Dr. Elvira van Dalen of the Emma Children抯 Hospital in the Netherlands.
She and her colleagues found that the rates of heart failure among adult patients receiving anthracycline therapy were significantly lower when the patients had an infusion of the drug that lasted six or more hours, compared to shorter infusions times.
In five studies involving 557 patients, the longer treatment cut the risk of heart failure by nearly 75 percent compared to the risk in patients who received the short treatment.
van Dalen said the prolonged dose of six hours or more 搈ight be justified?if a patient is at high risk of heart damage or needs a high cumulative dose of the chemotherapy.
The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.
In some of the studies, the prolonged dose also reduced the risk of less severe problems such as weakened heart function. Patients had the same chance of survival and tumor shrinkage whether they received the long or short therapies, the Cochrane researchers found.
揑t should be emphasized that the majority of the patients included in these studies were adults with advanced solid tumors,?van Dalen and colleagues said, noting that there are few good studies about the length of anthracycline treatment in children.
Among the children in the study, there was no difference in heart damage between the long and short treatments 揳nd no information on survival and tumor shrinkage was available,?van Dalen said.
Recent studies have shown that the toxic heart effects of anthracycline therapy can have lasting effects on children抯 health. Dr. Stephen Lipshulz, a pediatric cancer specialist at the University of Miami, said childhood cancer survivors 搈ay be at significant risk of serious cardiovascular problems at a much younger age," than researchers believed a few years ago.
Lipshulz抯 work suggests many childhood cancer survivors suffer from enlarged hearts and prematurely hardened arteries, due at least in part from their chemotherapy. 揑t抯 alarming that we抳e found such dramatic heart damage and blood vessel risk in some survivors who are just 10 or 15 years from treatment,?he said. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Longer anthracycline therapy reduces heart failure in adult cancer patients
对于成年癌症患者，较长时间的蒽环类抗生素治疗能减少心力衰竭的发生
Stretching out a dose of chemotherapy over six or more hours may reduce the risk of heart problems caused by certain commonly used cancer drugs, according to a new review of recent research.
根据一份新的对最近研究的综述，每剂化疗用药物的注入延长6小时或更长可时间减少某些常用的抗癌药物导致的心脏病的风险。
Anthracycline drugs like daunorubicin and doxorubicin are used to treat many types of solid tumors and blood cancers such as leukemias in adults and children.
蒽环类抗生素像柔红霉素和多柔比星用于治疗多类实体肿瘤和血癌，例如成人或儿童白血病
Anthracycline therapy can be very successful at controlling cancer, but heart damage caused by anthracycline treatment 搃s a considerable and serious problem,?said Dr. Elvira van Dalen of the Emma Children抯 Hospital in the Netherlands.
荷兰艾玛儿童医院的Elvira van Dalen博士说，蒽环类抗生素治疗可以非常成功的控制癌症，但是它所造成的心脏损害带了一个值得考虑的恶严重问题。
She and her colleagues found that the rates of heart failure among adult patients receiving anthracycline therapy were significantly lower when the patients had an infusion of the drug that lasted six or more hours, compared to shorter infusions times.
她和她的同事们发现在接受蒽环类抗生素治疗的成年患者中，药物滴注时间长达6小时或更长的患者发生心衰的比率比短时间滴注的患者更小。
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作者:admin@医学,生命科学 2011-05-07 17:11
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