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【medical-news】Leptin：心力衰竭患者肺功能预报的
Background: Leptin is a protein hormone produced by adipose tissue. Leptin has proinflammatory properties and is usually elevated in patients with chronic heart failure. We assessed if serum leptin relates to the loss in lung function in noncachectic patients with chronic heart failure.
Materials and methods: One hundred thirty-five consecutively eligible non-Hispanic white subjects (age, 24 to 79 years; 85 men and 50 women) with a diagnosis of stable systolic heart failure were recruited prospectively, along with 106 matched control subjects. FVC, FEV1, and single-breath diffusing capacity of the lung for carbon monoxide (DLCO) were measured by spirometry. Plasma leptin was measured by radioimmunoassay. Multiple linear regression was applied.
Results: The relationships of FEV1, FVC, and DLCO with leptin differed significantly between heart failure and control subjects after controlling for age, sex, percentage of body fat, and ejection fraction. In heart failure, leptin was as an independent predictor of FVC values (additional R2 = 0.05, p < 0.0001), FEV1 values (additional R2 = 0.05, p < 0.0001), and DLCO values (additional R2 = 0.14, p < 0.0001). In a final multiple regression model predicting lung function in heart failure, the independent effect of leptin was significant after further adjustments.
Conclusions: The predictive information provided by leptin is additive to that provided by measures of body fat in heart failure patients, especially for DLCO. Leptin may play a role in the impairment of lung function in subjects with heart failure.
Chest. 2008; 134:346-350 Leptin, a Novel Predictor of Lung Function in Heart Failure
Leptin：心力衰竭患者肺功能预报的一种新型因子
Background: Leptin is a protein hormone produced by adipose tissue. Leptin has proinflammatory properties and is usually elevated in patients with chronic heart failure. We assessed if serum leptin relates to the loss in lung function in noncachectic patients with chronic heart failure.
背景：Leptin是一种脂肪组织分泌的蛋白类激素，Leptin具有促炎作用，在慢性心力衰竭患者中体内浓度通常是增高的。我们评估非恶病质的慢性心力衰竭患者的血清leptin浓度是否与非功能丧失相关。
Materials and methods: One hundred thirty-five consecutively eligible non-Hispanic white subjects (age, 24 to 79 years; 85 men and 50 women) with a diagnosis of stable systolic heart failure were recruited prospectively, along with 106 matched control subjects. FVC, FEV1, and single-breath diffusing capacity of the lung for carbon monoxide (DLCO) were measured by spirometry. Plasma leptin was measured by radioimmunoassay. Multiple linear regression was applied.
资料与方法：对135例确诊收缩性心力衰竭的非西班牙裔白人受试者(年龄：24至 79 岁; 85 名男性，50名女性)进行前瞻性分析，另有106名受试者作为对照组。通过呼吸量测定法检测受试者FVC, FEV1,以及肺一氧化碳弥散量(DLCO)。并应用方面法测定血浆leptin浓度。统计方法应用多元线性回归分析。
Results: The relationships of FEV1, FVC, and DLCO with leptin differed significantly between heart failure and control subjects after controlling for age, sex, percentage of body fat, and ejection fraction. In heart failure, leptin was as an independent predictor of FVC values (additional R2 = 0.05, p < 0.0001), FEV1 values (additional R2 = 0.05, p < 0.0001), and DLCO values (additional R2 = 0.14, p < 0.0001). In a final multiple regression model predicting lung function in heart failure, the independent effect of leptin was significant after further adjustments.
结果：在去除年龄、性别、机体脂肪比例以及心脏射血指数等变量影响后，心力衰竭组和对照组患者的FEV1, FVC和 DLCO具有显著差异性。在心力衰竭患者中，leptin是一项独立的预测肺功能的独立指标：FVC (额外R2 = 0.05, p < 0.0001)；FEV1(额外 R2 = 0.05, p < 0.0001), DLCO (额外R2 = 0.14, p < 0.0001)。在心力衰竭患者中应用多重回归模型预测肺功能，在进一步调整变量后，leptin的独立影响作用更大。[标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-01-17 05:14
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