主页 > 医学新闻 >
【Brain】持续炎症可改变内源性神经干细胞的功能
Persistent inflammation alters the function of the endogenous brain stem cell compartment
Correspondence to: Gianvito Martino, MD, Neuroimmunology Unit – DIBIT and INSPE, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy E-mail: martino.gianvito@hsr.it
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation of non-migratory neuroblasts within the SVZ germinal niche. In parallel, we demonstrate a quantitative reduction of the putative brain stem cells proliferation in the SVZ during persistent brain inflammation, which is completely reversed after in vitro culture of the isolated NPCs. Together, these data indicate that the inflamed brain microenvironment sustains a non cell-autonomous dysfunction of the endogenous CNS stem cell compartment and challenge the potential efficacy of proposed therapies aimed at mobilizing endogenous precursors in chronic inflammatory brain disorders. 本人已认领本文翻译48小时若未提交请其他战友继续认领 Persistent inflammation alters the function of the endogenous brain stem cell compartment
持续炎症可改变内源性神经干细胞的功能
Correspondence to: Gianvito Martino, MD, Neuroimmunology Unit – DIBIT and INSPE, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy E-mail: martino.gianvito@hsr.it
通信：Gianvito Martino, MD, Neuroimmunology Unit – DIBIT and INSPE, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy E-mail: martino.gianvito@hsr.it
Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation of non-migratory neuroblasts within the SVZ germinal niche. In parallel, we demonstrate a quantitative reduction of the putative brain stem cells proliferation in the SVZ during persistent brain inflammation, which is completely reversed after in vitro culture of the isolated NPCs. Together, these data indicate that the inflamed brain microenvironment sustains a non cell-autonomous dysfunction of the endogenous CNS stem cell compartment and challenge the potential efficacy of proposed therapies aimed at mobilizing endogenous precursors in chronic inflammatory brain disorders.
内源性神经干细胞/母细胞（NPCs）被认为是促进组织平衡和创伤后修复的功能性仓库，因此最近提出了调动这些细胞的恢复疗法。尽管有证据证明在急性炎性反应刺激下神经发生增加（如缺血性休克），持续大脑炎症反应中内源性神经干细胞层的可塑性仍然没有被很好的阐明。在这里我们展示出由免疫细胞靶髓脂质介导的持续性大脑炎症反应，广泛的转变了体内室下区（SVZ）-定殖NPCs的增值和转移性质，导致了在SVZ生发层内显著的非转移神经母细胞堆积。我们同样证明了在持续性大脑炎症反应时，SVZ神经干细胞增值数量上的减少，这在离体NPCs的培养时完全相反。归纳以上，以上数据指出大脑炎症反应时内源性中枢神经系统干细胞层微环境存在非细胞自主的功能失调，并在慢性炎症反应时影响了针对内源性前体动员疗法的疗效潜能。
编译：
持续炎症可改变内源性神经干细胞的功能
通信：Gianvito Martino, MD, Neuroimmunology Unit – DIBIT and INSPE, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy E-mail: martino.gianvito@hsr.it
内源性神经干细胞/母细胞（NPCs）被认为是促进组织平衡和创伤后修复的功能性仓库，因此最近提出了调动这些细胞的恢复疗法。尽管有证据证明在急性炎性反应刺激下神经发生增加（如缺血性休克），持续大脑炎症反应中内源性神经干细胞层的可塑性仍然没有被很好的阐明。在这里我们展示出由免疫细胞靶髓脂质介导的持续性大脑炎症反应，广泛的转变了体内室下区（SVZ）-定殖NPCs的增值和转移性质，导致了在SVZ生发层内显著的非转移神经母细胞堆积。我们同样证明了在持续性大脑炎症反应时，SVZ神经干细胞增值数量上的减少，这在离体NPCs的培养时完全相反。归纳以上，以上数据指出大脑炎症反应时内源性中枢神经系统干细胞层微环境存在非细胞自主的功能失调，并在慢性炎症反应时影响了针对内源性前体动员疗法的疗效潜能。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-12-08 17:11
医学,生命科学网