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【medical-news】专家称，过度吸烟降低IVF成功机会
Wed Nov 8, 2006 8:13pm ET
By Patricia Reaney
LONDON (Reuters) - Heavy smokers are less likely to become pregnant through IVF treatment, even with donated eggs, fertility experts said on Thursday.
They found that smoking more than 10 cigarettes a day makes the womb less receptive to the embryo and reduces the odds that it will implant and result in a pregnancy.
Smoking has been known to affect a woman's fertility but Dr Sergio Soares, of the IVI Clinic in Lisbon and his team believe their findings are the first to show heavy smoking has an independent impact on the uterus.
"Cigarette smoking negatively affects pregnancy probability even when the eggs come from a non-smoker," he told Reuters. "This is the first time an effect of tobacco consumption has been demonstrated on the uterus."
He added that even if fertilisation takes place, heavy smokers have less chance of achieving a successful pregnancy.
The scientists compared the success rates of in-vitro fertilisation (IVF) treatments using donated eggs on 44 heavy smokers who puffed more than 10 cigarettes a day and 785 women who did not smoke or were light smokers.
All the women were married to non-smokers.
"The non-heavy smokers had a significantly higher pregnancy rate, with over half becoming pregnant (52.2 percent), compared with just over a third (34.1 percent) of the heavy smokers," Soares said.
He added that the findings, which are published in the journal Human Reproduction, show light smoking did not have any impact on the receptiveness of the uterus to the embryo.
Although heavy smokers were less likely to get pregnant, paradoxically there was a higher multiple pregnancy rate among them. Sixty percent of the heavy smokers had multiple births compared to 31 percent in the other group.
Soares said larger studies are needed to determine if components in tobacco affect the womb differently in various women -- impairing implantation in some women and having the reverse effect in others.
"It is already known that there is paradoxical dose-dependent effect of nicotine on ovarian tissue. Maybe the same effect is happening in uterine tissues," he added.
In addition to impairing fertility, smoking has also been shown to increase the risk of heart attack and stroke, respiratory problems and lung and other cancers.
Despite its macho advertising image, a recent study showed that men who smoked were more likely to suffer from impotence.
http://today.reuters.com/news/articlenews.aspx?type=healthNews&storyID=2006-11-09T011330Z_01_L08131552_RTRUKOC_0_US-SMOKING.xml&WTmodLoc=HealthNewsHome_C1_%5bFeed%5d-4 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Heavy smoking cuts chances of IVF success
Wed Nov 8, 2006 8:13pm ET
By Patricia Reaney
专家称，过度吸烟降低IVF成功机会
东部时间：2006年11月8日，星期三，下午8:13
Patricia Reaney报道
LONDON (Reuters) - Heavy smokers are less likely to become pregnant through IVF treatment, even with donated eggs, fertility experts said on Thursday.
伦敦（路透社）--周三，生育专家指出，过度吸烟者不易通过体外受精怀孕，即使使用捐助的卵子。
They found that smoking more than 10 cigarettes a day makes the womb less receptive to the embryo and reduces the odds that it will implant and result in a pregnancy.
他们发现，一天吸烟超过10支使得子宫对胚胎容受性降低，减少着床和受孕机会。
Smoking has been known to affect a woman's fertility but Dr Sergio Soares, of the IVI Clinic in Lisbon and his team believe their findings are the first to show heavy smoking has an independent impact on the uterus.
众所周知吸烟会影响女性生育。但是IVI（The Valencian Institute of Unfertility巴伦西亚不孕不育研究所）里斯本医疗中心的Sergio Soares博士和他的小组相信他们的发现第一个揭示了过度吸烟会对子宫产生独立的影响。
"Cigarette smoking negatively affects pregnancy probability even when the eggs come from a non-smoker," he told Reuters. "This is the first time an effect of tobacco consumption has been demonstrated on the uterus."
他告诉路投社说：“即使卵子采自非吸烟者，吸烟也会对受孕产生负面影响。这第一次证明了吸烟对子宫的影响。”
He added that even if fertilisation takes place, heavy smokers have less chance of achieving a successful pregnancy.
他还说，即使受精成功，过度吸烟者成功怀孕的机会也要比正常人小。
The scientists compared the success rates of in-vitro fertilisation (IVF) treatments using donated eggs on 44 heavy smokers who puffed more than 10 cigarettes a day and 785 women who did not smoke or were light smokers.
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作者:admin@医学,生命科学 2011-03-09 13:20
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