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【medical-news】胎记可能是儿童期癌危险性增加的
胎记可能是儿童期癌危险性增加的信号
http://www.medscape.com/viewarticle/557011
NEW YORK (Reuters Health) May 21 - The results of a study published in the May issue of Pediatrics suggest an association between childhood cancer and birthmarks, suggesting a possible shared etiology.
纽约路透社健康栏目5月21报道，发表在儿科学五月刊的一项研究结果表明，儿童期癌和胎记有相关性，可能与病因学有关。
Genetic syndromes and chromosomal anomalies are associated with a "markedly increased risk" of childhood malignancies, Dr. Julie A. Ross, of the University of Minnesota, Minneapolis, and colleagues point out. Study findings have suggested that minor malformations, such as birthmarks, may reflect "altered prenatal development," which could also increase the risk. In addition, children with acute lymphoblastic leukemia and rhabdomyosarcoma have been shown to have "a significant increased frequency of birthmarks."
遗传性综合征和染色体异常与儿童期恶性肿瘤“危险性显著增加”有相关性，Minneapolis市明尼苏达州大学的Julie A. Ross医师及其同事指出。研究发现表明，例如胎记这样的小畸形可以发映改变的胚胎发育，这种改变可能也增加恶性肿瘤的危险性。此外，患有急性淋巴细胞性白血病和横纹肌肉瘤的儿童出现胎记的几率显著增加。
To further investigate this relationship, the researchers used data from the Collaborative Perinatal Project cohort for 49,503 children born between 1959 and 1966. Birthmarks were documented as definite or suspected during the first year of life and included hemangiomas (strawberry and cavernous), port-wine stains, pigmented nevi, lymphangiomas, and caf-au-lait spots.
为了进一步研究这个相关性，研究人员使用了共同研究者关于出生在1959年至1966年间的49,503名儿童的围产期队列研究的数据。档案明确记载的胎记或生后一年内可疑的胎记以及包括草莓样和海绵状的血管瘤、葡萄酒色痣、色素痣、淋巴管瘤和牛奶咖啡斑。
Overall, 2505 children had a documented definite or suspected birthmark. A total of 47 children were diagnosed with cancer between 0 and 8 years. Of these, seven (15%) subjects had a definite or suspected birthmark documented during the first year of life.
整体的，2505名儿童有档案明确记载或可疑的胎记。共有47名儿童0到8岁期间诊断为癌，其中7例（占15%）出生后一年期间有明确或可疑的胎记的档案记载.
When all cancers were included, having a birthmark was associated with a significantly increased hazard of cancer (HR: 3.19). The risk was slightly attenuated when children diagnosed in the first year of life were excluded. The team notes that birthmarks did not appear to be associated with any specific childhood cancers.
对于所有癌，存在胎记与癌的危险性显著增加（危险比：3.19）的相关性。在儿童出生后一年内诊断排除后这危险性轻度降低。
Two possible relationships between birthmarks and cancer have been suggested. "First, insulin-like growth factor (IGF) system members IGF-1 and IGF-2 have been reported to be involved in the pathogenesis of infantile hemangiomas and also in Wilms' tumor, ALL, and AML," Dr. Ross's group notes.
表明胎记与癌有2个可能的关联，“第一，已有报道胰岛素样生长因子(IGF)家族成员的IGF-1和 IGF-2与婴儿性毛细血管瘤及Wilms肿瘤、急性淋巴细胞性白血病和急性单核细胞性白血病的发病有关”Ross医师的研究说。
"Second, both solid tumors and vascular anomalies (e.g., hemangiomas, port-wine stains) are known to have increased expression of angiogenic proteins, including vascular endothelial growth factor and basic fibroblast growth factor." And limited evidence implicates angiogenic proteins in the formation of hematopoietic cancers.
“第二，已知实体瘤和脉管异常（例如血管瘤、葡萄酒色痣）存在血管原的蛋白表达增加，包括血管内皮生长因子和碱性成纤维细胞生长因子。”但血管原的蛋白对血液相关癌的形成相应的资料有限。
Pediatrics 2007;119:e1088-e1093.
儿科学2007;119:e1088-e1093. 编译：629字
胎记可能是儿童期癌危险性增加的信号
纽约路透社健康栏目5月21报道，发表在儿科学五月刊的一项研究结果表明，儿童期癌和胎记有相关性，可能涉及病因学。
Minneapolis市明尼苏达州大学的Julie A. Ross医师及其同事指出，遗传性综合征和染色体异常与儿童期恶性肿瘤“危险性显著增加”有相关性。研究发现显示，如胎记这样的小畸形可以发映改变的胚胎发育，这种改变可能也增加恶性肿瘤的危险性。此外，患有急性淋巴细胞性白血病和横纹肌肉瘤的儿童出现胎记的几率显著增加。
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作者:admin@医学,生命科学 2011-03-04 17:11
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