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【medical-news】长期吸烟可能增加抑郁症发生危险
长期吸烟可能增加抑郁症发生危险
News Author: Karla Gale, MS
CME Author: Laurie Barclay, MD
Disclosures
发布
Release Date: June 1, 2007; Valid for credit through June 1, 2008 Credits Available
发布日期：2007年6月1日，
Physicians - maximum of 0.25 AMA PRA Category 1 Credit ™ for physicians;
医生
Family Physicians - up to 0.25 AAFP Prescribed credit for physicians
家庭医生
June 1, 2007 — Persistent smoking appears to be a predictor of depression symptoms, the results of a longitudinal study of Finnish twins suggest. On the other hand, investigators report in the May issue of Psychological Medicine, this association was not seen in individuals who stopped smoking many years ago.
2007-06-01—持续吸烟显示了对压力状况的预测，这是芬兰双胞胎经过长期调查学习提出的观点。另外，有调查者们于内科医药5月份期刊报道此的团体未调查已戒烟很多年的个体。
"Although nicotine in cigarettes has some mood-elevating properties, in the long-run chronic exposure to cigarette smoke may have a more important role in the etiology of depressive symptoms," lead author Dr. Tellervo Korhonen told Reuters Health.
“虽然烟草里的尼古丁有些兴奋神经的成分，从长远角度看长期暴露于烟草味中可能是抑郁症状病因中的一个较重要角色。”作者Tellervo Korhonen博士告诉路透社的健康版。
According to Dr. Korhonen, from the University of Helsinki, and her team, the underlying mechanism linking smoking and depression has not been identified. To investigate, the researchers used information from the Finnish Twin Cohort, a population-based database consisting of same-sex twin pairs born before 1958.
Korhonen博士来自赫尔辛基大学，她的团队正研究的吸烟和抑郁症之间的潜在关系还没有被证实。研究者门应用来自芬兰双胞胎队伍的信息，它人群数据基础包括1958年前出生的同性别双胞胎。
The current study was based on records from 10,977 men and women. Smoking status was determined by questionnaires conducted in 1975 and 1981. Twins who responded to at least one of the two earlier surveys were evaluated with the Beck Depression Inventory in 1990.
当前这项研究基于从10977男女中得来的信息记录。吸烟程度由1975和1981年间的调查表决定。经过上述其中一个调查的双胞胎们都由1990年的beck抑郁症评价表评价。
"The Beck Depression Inventory is a valid measure of screening depressive symptoms in a population-based study," Dr. Korhonen noted; it does not represent a clinical diagnosis. Her team defined a score > 9 as an indication of depressive symptoms.
“beck抑郁症评价表对以大量人群为基础的筛选抑郁症症状很有效的方法。”Korhonen博士指出；它并不代表临床诊断。她的队伍界定大于9分作为抑郁症症状的指征。
The authors used multiple logistic regression analyses, in which never-smokers were used as the reference category. They found that men were significantly more prone to depressive symptoms if they had reported smoking at the time of both earlier surveys (OR 1.42), or were smokers in 1971 who had quit by 1981 (OR 1.68).
作者们采用多元回归分析的统计学方法，其中从不吸烟的人被作为参照类。他们发现男人中如果较前两次调查中均已报到吸烟者明显有抑郁症状（OR 1.42），1971年的吸烟于1981年时已戒烟者也是如此（OR 1.68）。
Among women, the only significant predictive factor after adjustment was smoking as of 1975 followed by smoking cessation by 1981 (OR 1.38).
在女人中，仅有的矫正后有意义的预测因素是在1975年吸烟后1981年已戒烟的人群（OR 1.38）。
Only the men and women who smoked previously but had quit by the first survey in 1975 were not at increased risk of depressive symptoms, and may have even reduced the likelihood of depression by 1990.
1975年第一次调查前曾经吸烟但就已经戒烟的男女不在抑郁症危险增加因素中，而且至1990年甚至有降低抑郁症的倾向。
Persistent smoking appears to be the strongest predictor of depressive symptoms, the investigator added. In terms of the underlying mechanism, "it is very important to distinguish between the effects of acute nicotine ingestion and the consequences of chronic exposure to the multitude of noxious compounds contained in cigarette smoke (over 4000 compounds, many of them bioactive, cytotoxic, carcinogenic, or mutagenic)."
调查者们补充道，持续吸烟显示为抑郁症的最强预测因素，根据潜在的机制，分清急性吸收尼古丁作用和长期暴露于烟草的烟雾中所含的毒性复合物（超过4000种复合物，其中很多有生物毒性，细胞毒性，致癌物，致突变物）的叠加后果是非常重要的。
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作者:admin@医学,生命科学 2011-02-14 18:24
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