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【文摘发布】先有脑的结构改变，再有（轻度）
Author：Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR.
MRISC, Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536. csmith@mri.uky.edu
Resource: Neurology. 2007 Apr 17;68(16):1268-73
Abstract：OBJECTIVE: To determine whether alterations of brain structure in normal aged individuals precede the development of mild cognitive impairment (MCI) or Alzheimer disease (AD). BACKGROUND: Persons with MCI and AD demonstrate cortical volume losses vs asymptomatic aged individuals, particularly in the hippocampus, amygdala, and entorhinal cortex. It is unknown whether these losses or other volumetric changes are present, and to what degree, in cognitively normal individuals before the clinical diagnosis of MCI. METHODS: Structural MRI was performed on a cross-section of 136 longitudinally examined normal aged subjects. All subjects were cognitively normal at the time of their scan, but 23 later developed MCI, and 9 of these 23 went on to an AD diagnosis. Extracted volumes from voxel-based morphometric analysis were combined with clinical data to compare the 23 subjects who eventually developed MCI to 113 subjects who remained cognitively normal over an average follow-up of 5.4 years. RESULTS: Initially normal subjects who eventually developed MCI demonstrated decreased gray matter volumes in the anteromedial temporal lobes bilaterally and left angular gyrus while still cognitively normal. CONCLUSION: Structural brain changes in anatomic areas involved in higher cognitive processes precede clinical signs and symptoms in longitudinally followed normal subjects destined to develop mild cognitive impairment.
PMID: 17438217
发两篇对于脑的结构的研究的，这一篇是通过MRI来研究的。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title：Brain structural alterations before mild cognitive impairment.
标题：轻度认知功能障碍前的脑部结构改变
Author：Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR.
MRISC, Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536. csmith@mri.uky.edu
作者：：Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR.
MRISC,，来自肯塔基州，Lexington,800玫瑰街，肯塔基医学中心62号室
Resource: Neurology. 2007 Apr 17;68(16):1268-73
来源:《神经病学》杂志，2007年4月17日；68(16):1268-73
Abstract：摘要
OBJECTIVE: To determine whether alterations of brain structure in normal aged individuals precede the development of mild cognitive impairment (MCI) or Alzheimer disease (AD).
目的：评定在轻微认知障碍和阿尔茨海默病发生前是否在正常年龄个体中存在脑结构的变化
BACKGROUND: Persons with MCI and AD demonstrate cortical volume losses vs asymptomatic aged individuals, particularly in the hippocampus, amygdala, and entorhinal cortex. It is unknown whether these losses or other volumetric changes are present, and to what degree, in cognitively normal individuals before the clinical diagnosis of MCI.
背景：有MCI和AD的患者和无症状的同龄个体相比显示，在海马区，杏仁区和内嗅皮质区有显著的皮质层缺损。这是不能确定的,。在临床诊断轻微认知障碍前的正常认知个体，这些缺损或其它体积性变化,以及这种变化在何种程度上，尚不清楚。
METHODS: Structural MRI was performed on a cross-section of 136 longitudinally examined normal aged subjects. All subjects were cognitively normal at the time of their scan, but 23 later developed MCI, and 9 of these 23 went on to an AD diagnosis. Extracted volumes from voxel-based morphometric analysis were combined with clinical data to compare the 23 subjects who eventually developed MCI to 113 subjects who remained cognitively normal over an average follow-up of 5.4 years.
方法：用结构性核磁共振检查,对136例正常同龄受试者脑部横断面做纵向检查. 所有受试者在这次扫描中认知功能是正常的,但23例受试者后来发展成轻微认知障碍,同时这23例患者中有9例被诊断为阿尔茨海默病. 由(单一)容量成分形态测定分析提出的脑部体积并结合临床信息, 对这23例最终发展成MCI的受试者，和平均随访5.4年的113例受试者中其余的受试者做对比。
RESULTS: Initially normal subjects who eventually developed MCI demonstrated decreased gray matter volumes in the anteromedial temporal lobes bilaterally and left angular gyrus while still cognitively normal.
结果：起初那些最终发展成MCI的正常受试者显示出，在双侧颞叶前内侧和左角回脑脊髓灰质区存在体积缩小，但同时仍然能正常认知。
CONCLUSION: Structural brain changes in anatomic areas involved in higher cognitive processes precede clinical signs and symptoms in longitudinally followed normal subjects destined to develop mild cognitive impairment.
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作者:admin@医学,生命科学 2011-03-04 01:28
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