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【medical-news】使用猪模型评价胸腔封闭器表现：
Arnaud F, Tomori T, Teranishi K, Yun J, McCarron R, Mahon R
Naval Medical Research Center, Trauma and Resuscitative Medicine Department, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500, USA. francoise.arnaud@med.navy.mil
http://www.ncbi.nlm.nih.gov/sites/entrez
INTRODUCTION: Chest seals are externally applied devices used to treat an open pneumothorax. There is concern that chest seals used for treatment of an open pneumothorax can fail due to coagulation or malfunction of the external vent and poor skin adherence. Chest seal failure may lead to respiratory compromise or the development of a tension pneumothorax. The objective of this project was to compare the efficacy and adhesive capacity of two chest seals: Asherman and Bolin.
METHODS: An open pneumothorax model in the swine (30 kg) was developed to test the performance of Asherman (n=8) and Bolin (n=8) seals based on haemodynamic and ultrasonographic changes following intrathoracic air and blood infusion. Seal adherence measured on a scale from 0 (poor) to 3 (good) was tested on dry skin and skin soiled with blood.
RESULTS: After standardised perforation of the chest cavity and aperture blocking, an air infusion of 372 (S.D. 214 ml) was sufficient to reduce mean arterial pressure (MAP) by 20%. Both chest seals prevented a significant fall in MAP after infusion of 1500 ml air into the chest cavity, and had similar adherence scores (2.6 (S.D. 0.8) and 2.8 (S.D. 0.6)) on dry skin. However, on blood soiled skin the Bolin seal had a higher score (2.7 (S.D. 0.6) vs. 0.4 (S.D. 0.7); p<0.01). Ultrasound did not yield interpretable results to differentiate between Asherman and Bolin seals.
CONCLUSIONS: The Bolin and Asherman chest seals were equivalent in preventing the development of a tension pneumothorax in this open pneumothorax model. However, the Bolin chest seal demonstrated stronger adherence in blood soiled conditions.
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Evaluation of chest seal performance in a swine model: Comparison of Asherman vs. Bolin seal
使用猪模型评价胸腔封闭器表现：比较Asherman封闭器与Bolin封闭器
Summary
概要
Introduction
Chest seals are externally applied devices used to treat an open pneumothorax. There is concern that chest seals used for treatment of an open pneumothorax can fail due to coagulation or malfunction of the external vent and poor skin adherence. Chest seal failure may lead to respiratory compromise or the development of a tension pneumothorax. The objective of this project was to compare the efficacy and adhesive capacity of two chest seals: Asherman and Bolin.
介绍：
胸腔封闭器是常用治疗开放性气胸的装置。胸腔封闭器在治疗开放性气胸时可能因为体外通气口凝固或功能失常，以及皮肤黏附性差这两个倍受关注的因素而失败。胸腔封闭器失效可能会导致呼吸功能障碍或发展成为张力性气胸。本项目旨在比较Asherman和Bolin这两种胸腔封闭器的疗效和黏附能力。
Methods
An open pneumothorax model in the swine (30 kg) was developed to test the performance of Asherman (n = 8) and Bolin (n = 8) seals based on haemodynamic and ultrasonographic changes following intrathoracic air and blood infusion. Seal adherence measured on a scale from 0 (poor) to 3 (good) was tested on dry skin and skin soiled with blood.
方法：
使用一头30公斤的猪建立一个开放性气胸模型，通过检测胸腔内空气和血液灌注、血液动力学改变以及超声检查改变，以评价Asherman（n=8）和Bolin（n=8）的性能表现。在干燥皮肤和粘血皮肤上分别检测封闭器的皮肤黏附能力，标准为0（差）至3（好）。
Results
After standardised perforation of the chest cavity and aperture blocking, an air infusion of 372 (S.D. 214 ml) was sufficient to reduce mean arterial pressure (MAP) by 20%. Both chest seals prevented a significant fall in MAP after infusion of 1500 ml air into the chest cavity, and had similar adherence scores (2.6 (S.D. 0.8) and 2.8 (S.D. 0.6)) on dry skin. However, on blood soiled skin the Bolin seal had a higher score (2.7 (S.D. 0.6) vs. 0.4 (S.D. 0.7); p < 0.01). Ultrasound did not yield interpretable results to differentiate between Asherman and Bolin seals.
结果：
胸腔标准化穿孔并阻塞气孔后，注入372ml（标准差=214 ml）足以降低平均动脉压（MAP）20％。两种胸腔封闭器在注入1500ml空气后都能防止平均动脉压的大幅度下降，且在干燥皮肤上测得的皮肤黏附评分相似（2.6（标准差0.8）和2.8（标准差0.6））。然而在粘血皮肤上Bolin胸腔封闭器评分更高（2.7（标准差0.6）比0.4（标准差0.7）; p < 0.01）。超声检查的结果无法区分Asherman和Bolin这两种胸腔封闭器。
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作者:admin@医学,生命科学 2011-03-04 05:11
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